Difference between revisions of "YEL034W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000760 YEL034W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''HYP2 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''HYP2 '' | ||
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''TIF51A, eIF5A'' | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''TIF51A, eIF-5A, eIF5A'' |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]] | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]] | ||
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| − | '''Description of YEL034W:''' Translation | + | '''Description of YEL034W:''' Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication<ref name='S000113653'>Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 {{SGDpaper|S000113653}} PMID 16169922</ref><ref name='S000129817'>Gregio AP, et al. (2009) eIF5A has a function in the elongation step of translation in yeast. Biochem Biophys Res Commun 380(4):785-90 {{SGDpaper|S000129817}} PMID 19338753</ref><ref name='S000144853'>Henderson A and Hershey JW (2011) Eukaryotic translation initiation factor (eIF) 5A stimulates protein synthesis in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 108(16):6415-9 {{SGDpaper|S000144853}} PMID 21451136</ref><ref name='S000130229'>Saini P, et al. (2009) Hypusine-containing protein eIF5A promotes translation elongation. Nature 459(7243):118-21 {{SGDpaper|S000130229}} PMID 19424157</ref><ref name='S000040125'>Schwelberger HG, et al. (1993) Translation initiation factor eIF-5A expressed from either of two yeast genes or from human cDNA. Functional identity under aerobic and anaerobic conditions. J Biol Chem 268(19):14018-25 {{SGDpaper|S000040125}} PMID 8314769</ref><ref name='S000069868'>Valentini SR, et al. (2002) Genetic interactions of yeast eukaryotic translation initiation factor 5A (eIF5A) reveal connections to poly(A)-binding protein and protein kinase C signaling. Genetics 160(2):393-405 {{SGDpaper|S000069868}} PMID 11861547</ref><ref name='S000117998'>Zanelli CF, et al. (2006) eIF5A binds to translational machinery components and affects translation in yeast. Biochem Biophys Res Commun 348(4):1358-66 |
| − | {{SGDpaper| | + | {{SGDpaper|S000117998}} PMID 16914118</ref> |
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Latest revision as of 13:05, 20 September 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YEL034W |
| Gene name | HYP2 |
| Aliases | TIF51A, eIF-5A, eIF5A |
| Feature type | ORF, Verified |
| Coordinates | Chr V:85676..86149 |
| Primary SGDID | S000000760 |
Description of YEL034W: Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication[1][2][3][4][5][6][7]
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References
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- ↑ Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 SGD PMID 16169922
- ↑ Gregio AP, et al. (2009) eIF5A has a function in the elongation step of translation in yeast. Biochem Biophys Res Commun 380(4):785-90 SGD PMID 19338753
- ↑ Henderson A and Hershey JW (2011) Eukaryotic translation initiation factor (eIF) 5A stimulates protein synthesis in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 108(16):6415-9 SGD PMID 21451136
- ↑ Saini P, et al. (2009) Hypusine-containing protein eIF5A promotes translation elongation. Nature 459(7243):118-21 SGD PMID 19424157
- ↑ Schwelberger HG, et al. (1993) Translation initiation factor eIF-5A expressed from either of two yeast genes or from human cDNA. Functional identity under aerobic and anaerobic conditions. J Biol Chem 268(19):14018-25 SGD PMID 8314769
- ↑ Valentini SR, et al. (2002) Genetic interactions of yeast eukaryotic translation initiation factor 5A (eIF5A) reveal connections to poly(A)-binding protein and protein kinase C signaling. Genetics 160(2):393-405 SGD PMID 11861547
- ↑ Zanelli CF, et al. (2006) eIF5A binds to translational machinery components and affects translation in yeast. Biochem Biophys Res Commun 348(4):1358-66 SGD PMID 16914118
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