Difference between revisions of "YBR278W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000482 YBR278W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''DPB3 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''DPB3 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr II: | + | |nowrap| Chr II:760294..760899 |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000482 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000482 | ||
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| − | '''Description of YBR278W:''' Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) | + | '''Description of YBR278W:''' Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle<ref name='S000141383'>Aksenova A, et al. (2010) Mismatch Repair-Independent Increase in Spontaneous Mutagenesis in Yeast Lacking Non-Essential Subunits of DNA Polymerase epsilon. PLoS Genet 6(11):e1001209 {{SGDpaper|S000141383}} PMID 21124948</ref><ref name='S000051857'>Araki H, et al. (1991) Cloning DPB3, the gene encoding the third subunit of DNA polymerase II of Saccharomyces cerevisiae. Nucleic Acids Res 19(18):4867-72 {{SGDpaper|S000051857}} PMID 1923754</ref><ref name='S000075426'>Iida T and Araki H (2004) Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae. Mol Cell Biol 24(1):217-27 {{SGDpaper|S000075426}} PMID 14673157</ref><ref name='S000054633'>Li Y, et al. (2000) Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. J Biol Chem 275(30):23247-52 |
| − | + | {{SGDpaper|S000054633}} PMID 10801849</ref> | |
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Latest revision as of 13:05, 28 September 2012
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| Systematic name | YBR278W |
| Gene name | DPB3 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr II:760294..760899 |
| Primary SGDID | S000000482 |
Description of YBR278W: Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle[1][2][3][4]
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References
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- ↑ Aksenova A, et al. (2010) Mismatch Repair-Independent Increase in Spontaneous Mutagenesis in Yeast Lacking Non-Essential Subunits of DNA Polymerase epsilon. PLoS Genet 6(11):e1001209 SGD PMID 21124948
- ↑ Araki H, et al. (1991) Cloning DPB3, the gene encoding the third subunit of DNA polymerase II of Saccharomyces cerevisiae. Nucleic Acids Res 19(18):4867-72 SGD PMID 1923754
- ↑ Iida T and Araki H (2004) Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae. Mol Cell Biol 24(1):217-27 SGD PMID 14673157
- ↑ Li Y, et al. (2000) Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. J Biol Chem 275(30):23247-52 SGD PMID 10801849
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