Difference between revisions of "YDR283C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002691 YDR283C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002691 YDR283C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''GCN2 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''GCN2 ''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''AAS1''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''AAS1, AAS102, NDR2''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr IV:1030046..1025067
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|nowrap| Chr IV:1030049..1025070
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000002691
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000002691
 
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'''Description of YDR283C:''' Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex<ref name='S000072036'>Hinnebusch AG and Natarajan K (2002) Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress. Eukaryot Cell 1(1):22-32 {{SGDpaper|S000072036}} PMID 12455968</ref><ref name='S000063198'>Garcia-Barrio M, et al. (2000) Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation. EMBO J 19(8):1887-99 {{SGDpaper|S000063198}} PMID 10775272</ref><ref name='S000060332'>Kubota H, et al. (2001) Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2. J Biol Chem 276(20):17591-6
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'''Description of YDR283C:''' Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control<ref name='S000063198'>Garcia-Barrio M, et al. (2000) Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation. EMBO J 19(8):1887-99 {{SGDpaper|S000063198}} PMID 10775272</ref><ref name='S000072036'>Hinnebusch AG and Natarajan K (2002) Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress. Eukaryot Cell 1(1):22-32 {{SGDpaper|S000072036}} PMID 12455968</ref><ref name='S000060332'>Kubota H, et al. (2001) Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2. J Biol Chem 276(20):17591-6 {{SGDpaper|S000060332}} PMID 11350982</ref><ref name='S000124816'>Menacho-Marquez M, et al. (2007) Gcn2p regulates a G1/S cell cycle checkpoint in response to DNA damage. Cell Cycle 6(18):2302-5
  {{SGDpaper|S000060332}} PMID 11350982</ref>
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  {{SGDpaper|S000124816}} PMID 17890903</ref>
 
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Latest revision as of 06:45, 23 January 2012

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Systematic name YDR283C
Gene name GCN2
Aliases AAS1, AAS102, NDR2
Feature type ORF, Verified
Coordinates Chr IV:1030049..1025070
Primary SGDID S000002691


Description of YDR283C: Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control[1][2][3][4]




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References

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  1. Garcia-Barrio M, et al. (2000) Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation. EMBO J 19(8):1887-99 SGD PMID 10775272
  2. Hinnebusch AG and Natarajan K (2002) Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress. Eukaryot Cell 1(1):22-32 SGD PMID 12455968
  3. Kubota H, et al. (2001) Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2. J Biol Chem 276(20):17591-6 SGD PMID 11350982
  4. Menacho-Marquez M, et al. (2007) Gcn2p regulates a G1/S cell cycle checkpoint in response to DNA damage. Cell Cycle 6(18):2302-5 SGD PMID 17890903

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