Difference between revisions of "tL(UAA)Q"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=tL(UAA)Q tL(UAA)Q]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000007324 tL(UAA)Q]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||'' ''
 
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|nowrap| Mito:66095..66179
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000007324
 
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'''Description of {{PAGENAME}}:''' Mitochondrial tRNA-Leu, required for mitochondrial translation and indirectly for maintenance of the mitochondrial genome; mutations in the orthologous human gene cause the neurological disease MELAS<ref name='S000115647'>Feuermann M, et al. (2003) The yeast counterparts of human 'MELAS' mutations cause mitochondrial dysfunction that can be rescued by overexpression of the mitochondrial translation factor EF-Tu. EMBO Rep 4(1):53-8
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'''Description of tL(UAA)Q:''' Mitochondrial leucine tRNA (tRNA-Leu), predicted by tRNAscan-SE analysis; required for mitochondrial translation and indirectly for maintenance of the mitochondrial genome; mutations in the orthologous human gene cause the neurological disease MELAS<ref name='S000147623'>Chan PP and Lowe TM (2009) GtRNAdb: a database of transfer RNA genes detected in genomic sequence. Nucleic Acids Res 37(Database issue):D93-7 {{SGDpaper|S000147623}} PMID 18984615</ref><ref name='S000115647'>Feuermann M, et al. (2003) The yeast counterparts of human 'MELAS' mutations cause mitochondrial dysfunction that can be rescued by overexpression of the mitochondrial translation factor EF-Tu. EMBO Rep 4(1):53-8 {{SGDpaper|S000115647}} PMID 12524521</ref><ref name='S000058438'>Foury F, et al. (1998) The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae. FEBS Lett 440(3):325-31
  {{SGDpaper|S000115647}} PMID 12524521</ref>
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  {{SGDpaper|S000058438}} PMID 9872396</ref>
 
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==Community Commentary==
 
==Community Commentary==
 
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 06:45, 23 January 2012

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Systematic name tL(UAA)Q
Gene name
Aliases
Feature type tRNA
Coordinates Mito:66095..66179
Primary SGDID S000007324


Description of tL(UAA)Q: Mitochondrial leucine tRNA (tRNA-Leu), predicted by tRNAscan-SE analysis; required for mitochondrial translation and indirectly for maintenance of the mitochondrial genome; mutations in the orthologous human gene cause the neurological disease MELAS[1][2][3]




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References

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  1. Chan PP and Lowe TM (2009) GtRNAdb: a database of transfer RNA genes detected in genomic sequence. Nucleic Acids Res 37(Database issue):D93-7 SGD PMID 18984615
  2. Feuermann M, et al. (2003) The yeast counterparts of human 'MELAS' mutations cause mitochondrial dysfunction that can be rescued by overexpression of the mitochondrial translation factor EF-Tu. EMBO Rep 4(1):53-8 SGD PMID 12524521
  3. Foury F, et al. (1998) The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae. FEBS Lett 440(3):325-31 SGD PMID 9872396

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