Difference between revisions of "YLL043W"
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| − | The main role of Fps1 is export of glycerol for osmoregulation. Fps1 transport function is gated to ensure glycerol accummulation and glycerol release depending on osmotic conditions. | + | The main role of Fps1 is export of glycerol for osmoregulation. Fps1 transport function is gated to ensure glycerol accummulation and glycerol release depending on osmotic conditions. The mechanism of gating is not fully understood but requires certain conserved domains of Fps1 and, directly or indirectly, the Hog1 MAPK. |
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Revision as of 21:06, 22 June 2007
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| Systematic name | YLL043W |
| Gene name | FPS1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:49937..51946 |
| Primary SGDID | S000003966 |
Description of YLL043W: Plasma membrane glycerol channel, member of the major intrinsic protein (MIP) family of channel proteins; involved in efflux of glycerol and in uptake of the trivalent metalloids arsenite and antimonite[1][2][3]
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Contents
Community Commentary
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Protein Details
Protein Function/Process
Disruption of the FPS1 gene for the aquaglyceroporin Fps1p reduced uptake of 73As(III) into cells, conferring resistance to arsenite. The arsenate-resistant phenotype could be functionally complemented by expression of AQP9, a mammalian homologue [4] [5]
The main role of Fps1 is export of glycerol for osmoregulation. Fps1 transport function is gated to ensure glycerol accummulation and glycerol release depending on osmotic conditions. The mechanism of gating is not fully understood but requires certain conserved domains of Fps1 and, directly or indirectly, the Hog1 MAPK.
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References
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- ↑ Wysocki R, et al. (2001) The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiae. Mol Microbiol 40(6):1391-401 SGD PMID 11442837
- ↑ Luyten K, et al. (1995) Fps1, a yeast member of the MIP family of channel proteins, is a facilitator for glycerol uptake and efflux and is inactive under osmotic stress. EMBO J 14(7):1360-71 SGD PMID 7729414
- ↑ Tamas MJ, et al. (1999) Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation. Mol Microbiol 31(4):1087-104 SGD PMID 10096077
- ↑ Liu Z, et al. (2002) Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. Proc Natl Acad Sci U S A 99(9):6053-8 SGD PMID 11972053
- ↑ submitted by Barry Rosen on 2003-07-31
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References
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