Difference between revisions of "YOL090W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl? | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005450 YOL090W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MSH2 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MSH2 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
|nowrap| Chr XV:147382..150276 | |nowrap| Chr XV:147382..150276 | ||
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005450 | ||
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<br> | <br> | ||
| − | '''Description of | + | '''Description of YOL090W:''' Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP<ref name='S000073894'>Kijas AW, et al. (2003) Msh2 separation of function mutations confer defects in the initiation steps of mismatch repair. J Mol Biol 331(1):123-38 {{SGDpaper|S000073894}} PMID 12875840</ref><ref name='S000073568'>Antony E and Hingorani MM (2003) Mismatch recognition-coupled stabilization of Msh2-Msh6 in an ATP-bound state at the initiation of DNA repair. Biochemistry 42(25):7682-93 |
{{SGDpaper|S000073568}} PMID 12820877</ref> | {{SGDpaper|S000073568}} PMID 12820877</ref> | ||
<br> | <br> | ||
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J Biol Chem 278(5):3265-74</ref> | J Biol Chem 278(5):3265-74</ref> | ||
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Revision as of 07:46, 27 February 2007
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| Systematic name | YOL090W |
| Gene name | MSH2 |
| Aliases | PMS5 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:147382..150276 |
| Primary SGDID | S000005450 |
Description of YOL090W: Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP[1][2]
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References
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- ↑ Kijas AW, et al. (2003) Msh2 separation of function mutations confer defects in the initiation steps of mismatch repair. J Mol Biol 331(1):123-38 SGD PMID 12875840
- ↑ Antony E and Hingorani MM (2003) Mismatch recognition-coupled stabilization of Msh2-Msh6 in an ATP-bound state at the initiation of DNA repair. Biochemistry 42(25):7682-93 SGD PMID 12820877
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