Difference between revisions of "YNL068C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl? | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005012 YNL068C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''FKH2 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''FKH2 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
|nowrap| Chr XIV:498290..495702 | |nowrap| Chr XIV:498290..495702 | ||
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005012 | ||
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<br> | <br> | ||
| − | '''Description of | + | '''Description of YNL068C:''' Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase<ref name='S000079750'>Pic-Taylor A, et al. (2004) Regulation of cell cycle-specific gene expression through cyclin-dependent kinase-mediated phosphorylation of the forkhead transcription factor Fkh2p. Mol Cell Biol 24(22):10036-46 {{SGDpaper|S000079750}} PMID 15509804</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000073161'>Morillon A, et al. (2003) Regulation of elongating RNA polymerase II by forkhead transcription factors in yeast. Science 300(5618):492-5 {{SGDpaper|S000073161}} PMID 12702877</ref><ref name='S000066064'>Hollenhorst PC, et al. (2001) Mechanisms controlling differential promoter-occupancy by the yeast forkhead proteins Fkh1p and Fkh2p: implications for regulating the cell cycle and differentiation. Genes Dev 15(18):2445-56 {{SGDpaper|S000066064}} PMID 11562353</ref><ref name='S000060752'>Kumar R, et al. (2000) Forkhead transcription factors, Fkh1p and Fkh2p, collaborate with Mcm1p to control transcription required for M-phase. Curr Biol 10(15):896-906 {{SGDpaper|S000060752}} PMID 10959837</ref><ref name='S000053136'>Zhu G, et al. (2000) Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth. Nature 406(6791):90-4 {{SGDpaper|S000053136}} PMID 10894548</ref><ref name='S000050457'>Hollenhorst PC, et al. (2000) Forkhead genes in transcriptional silencing, cell morphology and the cell cycle. Overlapping and distinct functions for FKH1 and FKH2 in Saccharomyces cerevisiae. Genetics 154(4):1533-48 |
{{SGDpaper|S000050457}} PMID 10747051</ref> | {{SGDpaper|S000050457}} PMID 10747051</ref> | ||
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J Biol Chem 278(5):3265-74</ref> | J Biol Chem 278(5):3265-74</ref> | ||
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<protect> | <protect> | ||
Revision as of 08:46, 27 February 2007
Share your knowledge...Edit this entry! <protect>
| Systematic name | YNL068C |
| Gene name | FKH2 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:498290..495702 |
| Primary SGDID | S000005012 |
Description of YNL068C: Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase[1][2][3][4][5][6][7]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [2] [8]
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References
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- ↑ Pic-Taylor A, et al. (2004) Regulation of cell cycle-specific gene expression through cyclin-dependent kinase-mediated phosphorylation of the forkhead transcription factor Fkh2p. Mol Cell Biol 24(22):10036-46 SGD PMID 15509804
- ↑ 2.0 2.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ Morillon A, et al. (2003) Regulation of elongating RNA polymerase II by forkhead transcription factors in yeast. Science 300(5618):492-5 SGD PMID 12702877
- ↑ Hollenhorst PC, et al. (2001) Mechanisms controlling differential promoter-occupancy by the yeast forkhead proteins Fkh1p and Fkh2p: implications for regulating the cell cycle and differentiation. Genes Dev 15(18):2445-56 SGD PMID 11562353
- ↑ Kumar R, et al. (2000) Forkhead transcription factors, Fkh1p and Fkh2p, collaborate with Mcm1p to control transcription required for M-phase. Curr Biol 10(15):896-906 SGD PMID 10959837
- ↑ Zhu G, et al. (2000) Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth. Nature 406(6791):90-4 SGD PMID 10894548
- ↑ Hollenhorst PC, et al. (2000) Forkhead genes in transcriptional silencing, cell morphology and the cell cycle. Overlapping and distinct functions for FKH1 and FKH2 in Saccharomyces cerevisiae. Genetics 154(4):1533-48 SGD PMID 10747051
- ↑ submitted by Jeff Ubersax on 2004-01-29
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