Difference between revisions of "YLR079W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl? | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004069 YLR079W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SIC1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SIC1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
|nowrap| Chr XII:286821..287675 | |nowrap| Chr XII:286821..287675 | ||
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000004069 | ||
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| − | '''Description of | + | '''Description of YLR079W:''' Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1<ref name='S000080407'>Barberis M, et al. (2005) The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain. Biochem J 387(Pt 3):639-47 {{SGDpaper|S000080407}} PMID 15649124</ref><ref name='S000074398'>Nash P, et al. (2001) Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 414(6863):514-21 {{SGDpaper|S000074398}} PMID 11734846</ref><ref name='S000062149'>Verma R, et al. (1997) Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science 278(5337):455-60 {{SGDpaper|S000062149}} PMID 9334303</ref><ref name='S000058226'>Skowyra D, et al. (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91(2):209-19 {{SGDpaper|S000058226}} PMID 9346238</ref><ref name='S000057743'>Mendenhall MD (1993) An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae. Science 259(5092):216-9 {{SGDpaper|S000057743}} PMID 8421781</ref><ref name='S000050766'>Donovan JD, et al. (1994) P40SDB25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae. Genes Dev 8(14):1640-53 {{SGDpaper|S000050766}} PMID 7958845</ref><ref name='S000045057'>Nugroho TT and Mendenhall MD (1994) An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells. Mol Cell Biol 14(5):3320-8 {{SGDpaper|S000045057}} PMID 8164683</ref><ref name='S000043548'>Schwob E, et al. (1994) The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79(2):233-44 {{SGDpaper|S000043548}} PMID 7954792</ref><ref name='S000041398'>Feldman RM, et al. (1997) A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91(2):221-30 |
{{SGDpaper|S000041398}} PMID 9346239</ref> | {{SGDpaper|S000041398}} PMID 9346239</ref> | ||
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J Biol Chem 278(5):3265-74</ref> | J Biol Chem 278(5):3265-74</ref> | ||
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Revision as of 07:46, 27 February 2007
Share your knowledge...Edit this entry! <protect>
| Systematic name | YLR079W |
| Gene name | SIC1 |
| Aliases | SDB25 |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:286821..287675 |
| Primary SGDID | S000004069 |
Description of YLR079W: Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1[1][2][3][4][5][6][7][8][9]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [10] [11]
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References
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- ↑ Barberis M, et al. (2005) The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain. Biochem J 387(Pt 3):639-47 SGD PMID 15649124
- ↑ Nash P, et al. (2001) Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 414(6863):514-21 SGD PMID 11734846
- ↑ Verma R, et al. (1997) Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science 278(5337):455-60 SGD PMID 9334303
- ↑ Skowyra D, et al. (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91(2):209-19 SGD PMID 9346238
- ↑ Mendenhall MD (1993) An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae. Science 259(5092):216-9 SGD PMID 8421781
- ↑ Donovan JD, et al. (1994) P40SDB25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae. Genes Dev 8(14):1640-53 SGD PMID 7958845
- ↑ Nugroho TT and Mendenhall MD (1994) An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells. Mol Cell Biol 14(5):3320-8 SGD PMID 8164683
- ↑ Schwob E, et al. (1994) The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79(2):233-44 SGD PMID 7954792
- ↑ Feldman RM, et al. (1997) A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91(2):221-30 SGD PMID 9346239
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-29
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