Difference between revisions of "YLL050C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl? | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003973 YLL050C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''COF1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''COF1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
|nowrap| Chr XII:40413..39803 | |nowrap| Chr XII:40413..39803 | ||
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003973 | ||
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<br> | <br> | ||
| − | '''Description of | + | '''Description of YLL050C:''' Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments , thought to be regulated by phosphorylation at SER4, ubiquitous and essential in eukaryotes<ref name='S000062354'>Wriggers W, et al. (1998) Cofilin and gelsolin segment-1: molecular dynamics simulation and biochemical analysis predict a similar actin binding mode. J Mol Biol 282(5):921-32 {{SGDpaper|S000062354}} PMID 9753544</ref><ref name='S000058067'>Theriot JA (1997) Accelerating on a treadmill: ADF/cofilin promotes rapid actin filament turnover in the dynamic cytoskeleton. J Cell Biol 136(6):1165-8 {{SGDpaper|S000058067}} PMID 9087434</ref><ref name='S000056079'>Moriyama K, et al. (1996) Phosphorylation of Ser-3 of cofilin regulates its essential function on actin. Genes Cells 1(1):73-86 {{SGDpaper|S000056079}} PMID 9078368</ref><ref name='S000047128'>Iida K, et al. (1993) Isolation of a yeast essential gene, COF1, that encodes a homologue of mammalian cofilin, a low-M(r) actin-binding and depolymerizing protein. Gene 124(1):115-20 {{SGDpaper|S000047128}} PMID 8440472</ref><ref name='S000044417'>Ayscough KR, et al. (1997) High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A. J Cell Biol 137(2):399-416 {{SGDpaper|S000044417}} PMID 9128251</ref><ref name='S000039142'>Moon AL, et al. (1993) Cofilin is an essential component of the yeast cortical cytoskeleton. J Cell Biol 120(2):421-35 |
{{SGDpaper|S000039142}} PMID 8421056</ref> | {{SGDpaper|S000039142}} PMID 8421056</ref> | ||
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J Biol Chem 278(5):3265-74</ref> | J Biol Chem 278(5):3265-74</ref> | ||
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Revision as of 07:46, 27 February 2007
Share your knowledge...Edit this entry! <protect>
| Systematic name | YLL050C |
| Gene name | COF1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:40413..39803 |
| Primary SGDID | S000003973 |
Description of YLL050C: Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments , thought to be regulated by phosphorylation at SER4, ubiquitous and essential in eukaryotes[1][2][3][4][5][6]
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References
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- ↑ Wriggers W, et al. (1998) Cofilin and gelsolin segment-1: molecular dynamics simulation and biochemical analysis predict a similar actin binding mode. J Mol Biol 282(5):921-32 SGD PMID 9753544
- ↑ Theriot JA (1997) Accelerating on a treadmill: ADF/cofilin promotes rapid actin filament turnover in the dynamic cytoskeleton. J Cell Biol 136(6):1165-8 SGD PMID 9087434
- ↑ Moriyama K, et al. (1996) Phosphorylation of Ser-3 of cofilin regulates its essential function on actin. Genes Cells 1(1):73-86 SGD PMID 9078368
- ↑ Iida K, et al. (1993) Isolation of a yeast essential gene, COF1, that encodes a homologue of mammalian cofilin, a low-M(r) actin-binding and depolymerizing protein. Gene 124(1):115-20 SGD PMID 8440472
- ↑ Ayscough KR, et al. (1997) High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A. J Cell Biol 137(2):399-416 SGD PMID 9128251
- ↑ Moon AL, et al. (1993) Cofilin is an essential component of the yeast cortical cytoskeleton. J Cell Biol 120(2):421-35 SGD PMID 8421056
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