Difference between revisions of "YCL063W"
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{|{{Prettytable}} align = 'right' width = '200px' | {|{{Prettytable}} align = 'right' width = '200px' | ||
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− | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl? | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000568 YCL063W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''VAC17 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''VAC17 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
|nowrap| Chr III:17290..18561 | |nowrap| Chr III:17290..18561 | ||
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+ | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000568 | ||
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<br> | <br> | ||
− | '''Description of | + | '''Description of YCL063W:''' Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p<ref name='S000072781'>Ishikawa K, et al. (2003) Identification of an organelle-specific myosin V receptor. J Cell Biol 160(6):887-97 {{SGDpaper|S000072781}} PMID 12642614</ref><ref name='S000072665'>Tang F, et al. (2003) Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole. Nature 422(6927):87-92 |
{{SGDpaper|S000072665}} PMID 12594460</ref> | {{SGDpaper|S000072665}} PMID 12594460</ref> | ||
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J Biol Chem 278(5):3265-74</ref> | J Biol Chem 278(5):3265-74</ref> | ||
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<protect> | <protect> |
Revision as of 08:45, 27 February 2007
Share your knowledge...Edit this entry! <protect>
Systematic name | YCL063W |
Gene name | VAC17 |
Aliases | YCL062W |
Feature type | ORF, Verified |
Coordinates | Chr III:17290..18561 |
Primary SGDID | S000000568 |
Description of YCL063W: Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p[1][2]
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Contents
Community Commentary
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Alleles, Strains, and Phenotypes
Partial Deletion
Strain Background: LWY 7235
Genotype: LWY 5798 (vac17::TRP1)
Phenotype(s): Loss of function (Null), Recessive, Viable
Mutation type(s): Partial deletion from 17364 to partialDelTo
In LWY5798, residues 26-357 of Vac17p was substituted with the TRP1 gene. [2] [3]
Interactions
Physical
Physical interaction with VAC8
Immunoprecipitating Vac17p with sheep anti-Vac17p antibody coprecipitates Vac8p. [2] [3]
Physical interaction with MYO2
Immunoprecipitating Vac17p with sheep anti-Vac17p antibody coprecipitates Myo2p. [2] [3]
Two Hybrid
Two Hybrid interaction with VAC8
Residues 290-380 of Vac17p interact with Vac8p in a yeast two-hybrid analysis. [2] [3]
Protein Details
Protein Degradation
Vac17p contains a PEST sequence, a rapid degradation signal. The PEST-dependent degradation appears to occur in the bud after vacuoles arrive in the bud. [2] [3]
Protein Function/Process
Vac17p is involved in vacuole inheritance. Deletion of VAC17 gene blocks vacuole inheritance. Vac17p functions as the vacuole-specific Myp2p receptor. It forms a complex with Myo2p and Vac8p, a vacuolar membrane protein. Vac17p connects Myo2p to Vac8p and thus the vacuole membrane. [2] [3]
Protein Localization
Vac17p is localized on the vacuole membrane in a Vac8p-dependent manner. [2] [3]
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References
See Help:References on how to add references
- ↑ Ishikawa K, et al. (2003) Identification of an organelle-specific myosin V receptor. J Cell Biol 160(6):887-97 SGD PMID 12642614
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Tang F, et al. (2003) Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole. Nature 422(6927):87-92
SGD PMID 12594460 Cite error: Invalid
<ref>
tag; name "S000072665" defined multiple times with different content Cite error: Invalid<ref>
tag; name "S000072665" defined multiple times with different content Cite error: Invalid<ref>
tag; name "S000072665" defined multiple times with different content Cite error: Invalid<ref>
tag; name "S000072665" defined multiple times with different content Cite error: Invalid<ref>
tag; name "S000072665" defined multiple times with different content Cite error: Invalid<ref>
tag; name "S000072665" defined multiple times with different content Cite error: Invalid<ref>
tag; name "S000072665" defined multiple times with different content - ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 submitted by Fusheng Tang on 2003-03-17
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
- Pages with reference errors
- ORF
- ORF, Verified
- Topic:Alleles, Strains, and Phenotypes
- Topic:Alleles, Strains, and Phenotypes:Partial Deletion
- Phenotype:Loss of function (Null)
- Phenotype:Recessive
- Phenotype:Viable
- Topic:Interactions
- Topic:Interactions:Physical
- Physical Interactions with VAC8
- Physical Interactions with MYO2
- Topic:Interactions:Two Hybrid
- Two Hybrid Interactions with VAC8
- Topic:Protein Details
- Topic:Protein Details:Protein Degradation
- Topic:Protein Details:Protein Function/Process
- Topic:Protein Details:Protein Localization