Positions in yeast labs

Systems Chemical Biologist at Yumanity Therapeutics (posted 7 December 2018)

Description: Yumanity Therapeutics (http://www.yumanity.com/) is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Even though an estimated 50 million people worldwide suffer from diseases affecting the brain and central nervous system, there are no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address illnesses such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins, the altered biology or phenotypes driving these diseases.

Position Overview: The systems chemical biologist will work as an integral part of the target identification team, which uses large-scale forward and reverse genetic approaches to reveal the cellular targets of compounds discovered from phenotypic screens. The position reports to the target identification team lead, and will interact across all Yumanity’s core platforms, including chemistry, yeast screening, and mammalian validation. The successful candidate will become a key individual contributor in a dynamic and multidisciplinary environment. They will demonstrate a respect for others and be highly effective in a team.

For more information on this position, please visit the Yumanity careers page (http://www.yumanity.com/careers/). If you would like to apply, please submit your CV with the "Systems Chemical Biologist" in the subject line to careers@yumanity.com.

Postdoctoral Researcher or Research Scientist Position (1 position) in the Boone Team (RIKEN, Japan) (posted 7 December 2018)

A Postdoctoral Researcher or Research Scientist position is available in Dr. Charles Boone’s laboratory at RIKEN (http://www.riken.jp/en/research/labs/csrs/mol_ligand_targ). We are seeking a highly motivated candidate with strong expertise in yeast genetics/molecular biology and human cell culture experiments. The candidate will develop innovative techniques based on genetic networks in yeast and human cells that leads to quick and accurate detection of the ligand-target interactions.

How to apply: Please check the website (http://www.riken.jp/en/careers/researchers/20181129_5/) for the details.

Postdoctoral Position in Yeast Molecular Biology (posted 5 September 2018)

A NIH-funded postdoctoral position is available in the laboratory of Dr. David Kadosh in the Department of Microbiology, Immunology & Molecular Genetics at the University of Texas Health Science Center at San Antonio. Research will use cutting-edge techniques to study molecular mechanisms that control gene expression, morphology, virulence and virulence-related properties in response to host environmental cues in the yeast Candida albicans, a major human fungal pathogen. For additional details and previous publications, please see https://wp.uthscsa.edu/mimg/team-member/david-kadosh-ph-d/.

Highly motivated individuals with previous experience and a strong track record in molecular biology, genomics, cell biology, genetics, bioinformatics and/or protein chemistry are especially encouraged to apply. Previous experience in fungal pathogenesis is not necessarily required. Please send a cover letter outlining your research interests, CV, and contact information for three references to David Kadosh (kadosh@uthscsa.edu).

Many opportunities are available for collaboration with both basic and clinical researchers at the large and internationally recognized San Antonio Center for Medical Mycology (see http://www.sacmm.org/).

The successful applicant will receive equivalent to NIH-level salary and full benefits. Located in south central Texas, near both Austin and the Texas Hill Country, San Antonio is one of the lowest cost-of-living major metropolitan areas in the U.S.

All postdoctoral appointments are designated as security sensitive positions. The University of Texas Health Science Center at San Antonio is an Equal Employment Opportunity/Affirmative Action Employer.

The Kupiec lab is recruiting PhD students and post-docs (posted 2 July 2018)

Description: PhD positions and post-doctoral research positions are available in Prof. Martin Kupiec’s laboratory at Tel Aviv University (https://mkyeastlab.wixsite.com/mklab). We work with yeast (S. cerevisiae and S. pombe) exploring the role of Elg1 and other proteins in genome stability maintenance and telomere biology. Additional projects include exploring the interphase between DNA replication, chromatin modifications, sister-chromatid cohesion and DNA repair.

We are seeking highly motivated candidates with expertise in molecular biology and genetics. Experience in yeast genetics is desirable, but not a requirement. Independence, communication and interpersonal skills are valued in order to work in a young, dynamic, diverse, and collaborative environment. We are an international team, and research is carried out in English.

How to apply: Prospective candidates should submit a cover letter describing their research experience, scientific interest, career goals, and motivation to apply for this position. Please include an updated CV and the contact information of at least two references. Questions should be directed to Prof. Martin Kupiec at martin@post.tau.ac.il.

Synthetic Molecular Biologist (posted 17 January 2018)

Gadusol Laboratories, a new biotech startup, has an immediate opening for a qualified and motivated full-time Synthetic Molecular Biologist at our Corvallis, Oregon laboratory.

Job Description:
Manage a 12-month National Science Foundation SBIR Phase I research effort to produce marine-based sunscreens in yeast. The position includes executing a scope of work focused on attaining high yields of recombinant sunscreen compounds in yeast and entails all aspects of research management, including but not limited to: fulfilling all grant requirements of a Principal Investigator, reporting, laboratory maintenance, and performing various operational and administrative activities as needed. The candidate we seek is comfortable working independently, adapts well to change, is willing to work closely with senior management to help secure follow-on funding (i.e., contribute to SBIR Phase 2 proposal development), and enjoys working in fast-paced startup environment with room for growth.

The position requires some travel.

Requirements:

• Ph.D. in Microbiology, Biology, Genetics, or Biochemistry
• Experience with yeast molecular genetics preferred
• Interest in working for a startup and participating in strategic growth
• Travel to a key conference occurring March 18 – 21, 2018

Salary: Commensurate with experience.

Please send a resume and cover letter to info@gadusollabs.com for consideration.

Postdoc Position in Ubiquitination and Stress Response at Duke University (posted 08 November 2017)

Description: A post-doctoral research position is available in Dr. Gustavo Silva’s laboratory at Duke University (https://sites.duke.edu/silvalab). The prospective candidate will develop research focused on understanding the role of protein ubiquitination and protein dynamics during cellular response to stress. The lab uses a combination of molecular and large scale approaches, including mass spectrometry-based proteomics and next generation sequencing, to elucidate signaling pathways in yeast and mammalian cells.

Candidate: We are seeking a highly motivated candidate with strong expertise in molecular cloning, recombinant protein, and yeast genetics to fulfill this position. Additional experience in proteomics, genomics, and/or computational biology will be favored and is desirable, but not a requirement. Communication and interpersonal skills are valued in order to work in a young, dynamic, diverse, and collaborative environment

How to apply:Prospective candidates should submit a cover letter describing their research experience, scientific interest, career goals, and motivation to apply for this position. Please include an updated CV and the contact information of three references. Questions should be directed to Dr. Silva at gustavo.silva@duke.edu and applications must be submitted via Academic Jobs Online: https://academicjobsonline.org/ajo/jobs/10359

Postdoc Opening - Autophagy of lipid droplets in YEAST (posted 29 August 2017)

Postdoctoral project: Autophagy of lipid droplets in YEAST

Academic institution: University of California, San Diego

Academic division: Division of Biological Sciences

Academic unit: Section of Molecular Biology

Description: Applications are invited for a postdoctoral position in the group of Taras Nazarko studying mechanisms of lipophagy, the selective autophagy of lipid droplets (LDs). Lipophagy is accomplished by delivery of LDs from the cytosol to the lysosome (or vacuole in yeast). As in other autophagic pathways, the core autophagic machinery forms the autophagic isolation membrane that sequesters the LD from the cytosol. However, how this autophagic membrane recognizes the LD after lipophagy induction is unknown. Also, it is not clear how lipophagy is kept in check the rest of the time. Therefore, lipophagy selectivity and regulation are the key gaps in our understanding of this pathway. A postdoctoral scholar will develop a project in one of these areas. Mechanistic understanding in these areas is critical for the precise control of lipophagy in humans for the prevention and treatment of various lipid accumulation diseases, like atherosclerosis and obesity. Initial appointment is for 1 year with possible extension for up to 5 years of overall postdoctoral training. Salary is commensurate with experience (http://postdoc.ucsd.edu/appointment-guidelines/).

Applicant requirements: The successful applicants will have a recent PhD in biochemistry, genetics, molecular or cell biology and a strong background in YEAST genetics, protein biochemistry and fluorescence microscopy. Expertise with mammalian cells or zebrafish model is a plus but not essential. Preference will be given to candidates with experience in autophagy pathway or with LDs.

How to apply: Please send your cover letter, CV and contact information of 3 references to Taras Nazarko, tnazarko@ucsd.edu