Difference between revisions of "YNL176C"
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| + | Transmembrane Domain GxxxG | ||
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| + | The transmembrane domain of Tda7p shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain contains GtivGsvvGsvgG. The presence of multiple, chained GxxxG motifs <ref name='PMID 15313242'> Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242</ref> strongly indicates that Tda7p multimerises. | ||
Revision as of 08:16, 21 March 2013
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| Systematic name | YNL176C |
| Gene name | TDA7 |
| Aliases | |
| Feature type | ORF, Uncharacterized |
| Coordinates | Chr XIV:306980..305070 |
| Primary SGDID | S000005120 |
Description of YNL176C: Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele[1][2]
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Contents
Community Commentary
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Transmembrane Domain GxxxG
The transmembrane domain of Tda7p shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain contains GtivGsvvGsvgG. The presence of multiple, chained GxxxG motifs [3] strongly indicates that Tda7p multimerises.
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References
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- ↑ Reid RJ, et al. (2011) Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage. Genome Res 21(3):477-86 SGD PMID 21173034
- ↑ de Lichtenberg U, et al. (2005) New weakly expressed cell cycle-regulated genes in yeast. Yeast 22(15):1191-201 SGD PMID 16278933
- ↑ Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242
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