Difference between revisions of "YCR066W"
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| − | '''Description of YCR066W:''' E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair<ref name='S000051450'>Bailly V, et al. (1997) Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding, and ATP hydrolytic activities. J Biol Chem 272(37):23360-5 {{SGDpaper|S000051450}} PMID 9287349</ref><ref name='S000131245'>Ulrich HD (2009) Regulating post-translational modifications of the eukaryotic replication clamp PCNA. DNA Repair (Amst) 8(4):461-9 | + | '''Description of YCR066W:''' E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA<ref name='S000051450'>Bailly V, et al. (1997) Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding, and ATP hydrolytic activities. J Biol Chem 272(37):23360-5 {{SGDpaper|S000051450}} PMID 9287349</ref><ref name='S000151213'>Parker JL and Ulrich HD (2012) A SUMO-interacting motif activates budding yeast ubiquitin ligase Rad18 towards SUMO-modified PCNA. Nucleic Acids Res () {{SGDpaper|S000151213}} PMID 23034805</ref><ref name='S000131245'>Ulrich HD (2009) Regulating post-translational modifications of the eukaryotic replication clamp PCNA. DNA Repair (Amst) 8(4):461-9 |
{{SGDpaper|S000131245}} PMID 19217833</ref> | {{SGDpaper|S000131245}} PMID 19217833</ref> | ||
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Latest revision as of 13:05, 18 October 2012
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| Systematic name | YCR066W |
| Gene name | RAD18 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr III:231500..232963 |
| Primary SGDID | S000000662 |
Description of YCR066W: E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA[1][2][3]
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References
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- ↑ Bailly V, et al. (1997) Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding, and ATP hydrolytic activities. J Biol Chem 272(37):23360-5 SGD PMID 9287349
- ↑ Parker JL and Ulrich HD (2012) A SUMO-interacting motif activates budding yeast ubiquitin ligase Rad18 towards SUMO-modified PCNA. Nucleic Acids Res () SGD PMID 23034805
- ↑ Ulrich HD (2009) Regulating post-translational modifications of the eukaryotic replication clamp PCNA. DNA Repair (Amst) 8(4):461-9 SGD PMID 19217833
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