Difference between revisions of "YPR175W"
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| − | '''Description of YPR175W:''' Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for | + | '''Description of YPR175W:''' Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for maintenance of fidelity of chromosomal replication; expression peaks at the G1/S phase boundary; Cdc28p substrate<ref name='S000052399'>Araki H, et al. (1991) DPB2, the gene encoding DNA polymerase II subunit B, is required for chromosome replication in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 88(11):4601-5 {{SGDpaper|S000052399}} PMID 2052544</ref><ref name='S000125441'>Jaszczur M, et al. (2008) Dpb2p, a Noncatalytic Subunit of DNA Polymerase {varepsilon}, Contributes to the Fidelity of DNA Replication in Saccharomyces cerevisiae. Genetics 178(2):633-47 {{SGDpaper|S000125441}} PMID 18245343</ref><ref name='S000130431'>Jaszczur M, et al. (2009) Defective interaction between Pol2p and Dpb2p, subunits of DNA polymerase epsilon, contributes to a mutator phenotype in Saccharomyces cerevisiae. Mutat Res 669(1-2):27-35 |
| − | {{SGDpaper| | + | {{SGDpaper|S000130431}} PMID 19463834</ref> |
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Latest revision as of 14:05, 15 October 2012
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| Systematic name | YPR175W |
| Gene name | DPB2 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:888974..891043 |
| Primary SGDID | S000006379 |
Description of YPR175W: Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for maintenance of fidelity of chromosomal replication; expression peaks at the G1/S phase boundary; Cdc28p substrate[1][2][3]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [5]
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References
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- ↑ Araki H, et al. (1991) DPB2, the gene encoding DNA polymerase II subunit B, is required for chromosome replication in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 88(11):4601-5 SGD PMID 2052544
- ↑ Jaszczur M, et al. (2008) Dpb2p, a Noncatalytic Subunit of DNA Polymerase {varepsilon}, Contributes to the Fidelity of DNA Replication in Saccharomyces cerevisiae. Genetics 178(2):633-47 SGD PMID 18245343
- ↑ Jaszczur M, et al. (2009) Defective interaction between Pol2p and Dpb2p, subunits of DNA polymerase epsilon, contributes to a mutator phenotype in Saccharomyces cerevisiae. Mutat Res 669(1-2):27-35 SGD PMID 19463834
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-29
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