Difference between revisions of "YBR107C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000311 YBR107C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''IML3 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''IML3 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr II: | + | |nowrap| Chr II:454530..453793 |
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000311 | ||
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| − | '''Description of {{ | + | '''Description of YBR107C:''' Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1<ref name='S000131456'>Fernius J and Marston AL (2009) Establishment of cohesion at the pericentromere by the Ctf19 kinetochore subcomplex and the replication fork-associated factor, Csm3. PLoS Genet 5(9):e1000629 {{SGDpaper|S000131456}} PMID 19730685</ref><ref name='S000060304'>Ghosh SK, et al. (2001) The IML3/MCM19 gene of Saccharomyces cerevisiae is required for a kinetochore-related process during chromosome segregation. Mol Genet Genomics 265(2):249-57 {{SGDpaper|S000060304}} PMID 11361335</ref><ref name='S000080932'>Ghosh SK, et al. (2004) The Iml3 protein of the budding yeast is required for the prevention of precocious sister chromatid separation in meiosis I and for sister chromatid disjunction in meiosis II. Curr Genet 46(2):82-91 {{SGDpaper|S000080932}} PMID 15241623</ref><ref name='S000074151'>Pot I, et al. (2003) Chl4p and iml3p are two new members of the budding yeast outer kinetochore. Mol Biol Cell 14(2):460-76 {{SGDpaper|S000074151}} PMID 12589047</ref><ref name='S000149670'>Schleiffer A, et al. (2012) CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nat Cell Biol 14(6):604-13 |
| − | {{SGDpaper| | + | {{SGDpaper|S000149670}} PMID 22561346</ref> |
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==Community Commentary== | ==Community Commentary== | ||
{{CommentaryHelp}} | {{CommentaryHelp}} | ||
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| + | <!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation --> | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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Latest revision as of 13:05, 9 October 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YBR107C |
| Gene name | IML3 |
| Aliases | MCM19 |
| Feature type | ORF, Verified |
| Coordinates | Chr II:454530..453793 |
| Primary SGDID | S000000311 |
Description of YBR107C: Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1[1][2][3][4][5]
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Community Commentary
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References
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- ↑ Fernius J and Marston AL (2009) Establishment of cohesion at the pericentromere by the Ctf19 kinetochore subcomplex and the replication fork-associated factor, Csm3. PLoS Genet 5(9):e1000629 SGD PMID 19730685
- ↑ Ghosh SK, et al. (2001) The IML3/MCM19 gene of Saccharomyces cerevisiae is required for a kinetochore-related process during chromosome segregation. Mol Genet Genomics 265(2):249-57 SGD PMID 11361335
- ↑ Ghosh SK, et al. (2004) The Iml3 protein of the budding yeast is required for the prevention of precocious sister chromatid separation in meiosis I and for sister chromatid disjunction in meiosis II. Curr Genet 46(2):82-91 SGD PMID 15241623
- ↑ Pot I, et al. (2003) Chl4p and iml3p are two new members of the budding yeast outer kinetochore. Mol Biol Cell 14(2):460-76 SGD PMID 12589047
- ↑ Schleiffer A, et al. (2012) CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nat Cell Biol 14(6):604-13 SGD PMID 22561346
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