Difference between revisions of "YLR035C"

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'''Description of {{PAGENAME}}:''' Protein required for DNA mismatch repair in mitosis and meiosis; involved in the repair of mutational intermediates; forms a complex with Pms1p and Msh1p to repair mismatched DNA<ref name='S000057873'>Kolodner R (1996) Biochemistry and genetics of eukaryotic mismatch repair. Genes Dev 10(12):1433-42 {{SGDpaper|S000057873}} PMID 8666228</ref><ref name='S000042567'>Harfe BD, et al. (2000) Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast. Curr Biol 10(3):145-8
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'''Description of {{PAGENAME}}:''' Protein required for DNA mismatch repair in mitosis; involved in the repair of mutational intermediates; forms a complex with Pms1p and Msh1p to repair mismatched DNA<ref name='S000057873'>Kolodner R (1996) Biochemistry and genetics of eukaryotic mismatch repair. Genes Dev 10(12):1433-42 {{SGDpaper|S000057873}} PMID 8666228</ref><ref name='S000042567'>Harfe BD, et al. (2000) Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast. Curr Biol 10(3):145-8
 
  {{SGDpaper|S000042567}} PMID 10679328</ref>
 
  {{SGDpaper|S000042567}} PMID 10679328</ref>
 
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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Revision as of 13:02, 21 February 2007

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Systematic name YLR035C
Gene name MLH2
Aliases
Feature type ORF, Verified
Coordinates Chr XII:214457..212370


Description of YLR035C: Protein required for DNA mismatch repair in mitosis; involved in the repair of mutational intermediates; forms a complex with Pms1p and Msh1p to repair mismatched DNA[1][2]




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Community Commentary

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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [3] [4]




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References

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  1. Kolodner R (1996) Biochemistry and genetics of eukaryotic mismatch repair. Genes Dev 10(12):1433-42 SGD PMID 8666228
  2. Harfe BD, et al. (2000) Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast. Curr Biol 10(3):145-8 SGD PMID 10679328
  3. Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  4. submitted by Jeff Ubersax on 2004-01-29

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