Difference between revisions of "YIR019C"
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{|{{Prettytable}} align = 'right' width = '200px' | {|{{Prettytable}} align = 'right' width = '200px' | ||
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001458 YIR019C] |
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||'' | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''FLO11 '' |
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''MUC1, STA4'' |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]] | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]] | ||
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr IX: | + | |nowrap| Chr IX:393675..389572 |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000001458 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000001458 | ||
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| − | '''Description of YIR019C:''' GPI-anchored cell surface glycoprotein required for | + | '''Description of YIR019C:''' GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); required for the formation of fibrous interconnections between cells in a colony of a wild S. cerevisiae strain<ref name='S000124375'>Douglas LM, et al. (2007) Expression and Characterization of the Flocculin Flo11/Muc1, a Saccharomyces cerevisiae Mannoprotein with Homotypic Properties of Adhesion. Eukaryot Cell 6(12):2214-21 {{SGDpaper|S000124375}} PMID 17921350</ref><ref name='S000061547'>Guo B, et al. (2000) A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating. Proc Natl Acad Sci U S A 97(22):12158-63 {{SGDpaper|S000061547}} PMID 11027318</ref><ref name='S000055959'>Lambrechts MG, et al. (1996) Muc1, a mucin-like protein that is regulated by Mss10, is critical for pseudohyphal differentiation in yeast. Proc Natl Acad Sci U S A 93(16):8419-24 {{SGDpaper|S000055959}} PMID 8710886</ref><ref name='S000051172'>Rupp S, et al. (1999) MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. EMBO J 18(5):1257-69 {{SGDpaper|S000051172}} PMID 10064592</ref><ref name='S000146665'>Vachova L, et al. (2011) Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies. J Cell Biol 194(5):679-87 |
| − | {{SGDpaper| | + | {{SGDpaper|S000146665}} PMID 21875945</ref> |
<br> | <br> | ||
<br> | <br> | ||
Latest revision as of 13:05, 20 September 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YIR019C |
| Gene name | FLO11 |
| Aliases | MUC1, STA4 |
| Feature type | ORF, Verified |
| Coordinates | Chr IX:393675..389572 |
| Primary SGDID | S000001458 |
Description of YIR019C: GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); required for the formation of fibrous interconnections between cells in a colony of a wild S. cerevisiae strain[1][2][3][4][5]
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Contents
Community Commentary
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Alleles, Strains, and Phenotypes
Multiple Knockout Strains
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4618
Together with: REG1, SIP1, GAL83, SIP2
Phenotype(s): Loss of function (Null), FLO11/MUC1 promoter substituted with S.p.Adh+ promoter
Deletion of REG1 in cells where FLO11/MUC1 expression is clamped (by substitution of the FLO11 promoter with the S.pombe Adh+promoter) causes an increase in invasion. [6] [7]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4469
Together with: REG1, SIP1, GAL83, SIP2
Phenotype(s): Loss of function (Null)
Deletion of FLO11/MUC1 suppresses reg1's constitutive invasion phenotype, but not its constitutive filamentous phenotype. [6] [7]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4618
Together with: REG1, SIP1, GAL83, SIP2
Phenotype(s): Loss of function (Null), FLO11/MUC1 promoter substituted with S.p.Adh+ promoter
Deletion of REG1 in cells where FLO11/MUC1 expression is clamped (by substitution of the FLO11 promoter with the S.pombe Adh+promoter) causes an increase in invasion. [6] [7]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4469
Together with: REG1, SIP1, GAL83, SIP2
Phenotype(s): Loss of function (Null)
Deletion of FLO11/MUC1 suppresses reg1's constitutive invasion phenotype, but not its constitutive filamentous phenotype. [6] [7]
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References
See Help:References on how to add references
- ↑ Douglas LM, et al. (2007) Expression and Characterization of the Flocculin Flo11/Muc1, a Saccharomyces cerevisiae Mannoprotein with Homotypic Properties of Adhesion. Eukaryot Cell 6(12):2214-21 SGD PMID 17921350
- ↑ Guo B, et al. (2000) A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating. Proc Natl Acad Sci U S A 97(22):12158-63 SGD PMID 11027318
- ↑ Lambrechts MG, et al. (1996) Muc1, a mucin-like protein that is regulated by Mss10, is critical for pseudohyphal differentiation in yeast. Proc Natl Acad Sci U S A 93(16):8419-24 SGD PMID 8710886
- ↑ Rupp S, et al. (1999) MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. EMBO J 18(5):1257-69 SGD PMID 10064592
- ↑ Vachova L, et al. (2011) Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies. J Cell Biol 194(5):679-87 SGD PMID 21875945
- ↑ 6.0 6.1 6.2 6.3 Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 SGD PMID 12556493
- ↑ 7.0 7.1 7.2 7.3 submitted by Valmik K. Vyas on 2003-03-27
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