Difference between revisions of "YEL031W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YEL031W YEL031W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000757 YEL031W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SPF1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SPF1 ''
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|nowrap| Chr V:90258..93905
 
|nowrap| Chr V:90258..93905
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000000757
 
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'''Description of {{PAGENAME}}:''' P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1<ref name='S000070157'>Cronin SR, et al. (2002) Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis. J Cell Biol 157(6):1017-28 {{SGDpaper|S000070157}} PMID 12058017</ref><ref name='S000051798'>Cronin SR, et al. (2000) Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p. J Cell Biol 148(5):915-24 {{SGDpaper|S000051798}} PMID 10704442</ref><ref name='S000043545'>Suzuki C and Shimma YI (1999) P-type ATPase spf1 mutants show a novel resistance mechanism for the killer toxin SMKT. Mol Microbiol 32(4):813-23
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'''Description of YEL031W:''' P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1<ref name='S000051798'>Cronin SR, et al. (2000) Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p. J Cell Biol 148(5):915-24 {{SGDpaper|S000051798}} PMID 10704442</ref><ref name='S000070157'>Cronin SR, et al. (2002) Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis. J Cell Biol 157(6):1017-28 {{SGDpaper|S000070157}} PMID 12058017</ref><ref name='S000150715'>Katrin K, et al. (2012) Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes. Mol Biol Cell () {{SGDpaper|S000150715}} PMID 22918956</ref><ref name='S000043545'>Suzuki C and Shimma YI (1999) P-type ATPase spf1 mutants show a novel resistance mechanism for the killer toxin SMKT. Mol Microbiol 32(4):813-23
 
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==Community Commentary==
 
==Community Commentary==
 
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=== Alleles, Strains, and Phenotypes ===
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[[Category:Topic:Alleles, Strains, and Phenotypes]]
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==== Complete Deletion ====
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[[Category:Topic:Alleles, Strains, and Phenotypes:Complete Deletion]]
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'''Genotype''': RHY1202<br>
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'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]], Recessive [[Category:Phenotype:Recessive]], Viable [[Category:Phenotype:Viable]]
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Deletion of COD1/SPF1 prevents the degradation of Hmg2p from being regulated. <ref name='S000051798'>Cronin SR, et al. (2000) Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p. J Cell Biol 148(5):915-24 {{SGDpaper|S000051798}} PMID 10704442</ref> <ref name = 'CAset1165-2003-06-13'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=1165 Stephen R. Cronin] on 2003-06-13</ref>
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 13:05, 14 September 2012

Share your knowledge...Edit this entry! <protect>

Systematic name YEL031W
Gene name SPF1
Aliases COD1, PER9, PIO1
Feature type ORF, Verified
Coordinates Chr V:90258..93905
Primary SGDID S000000757


Description of YEL031W: P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1[1][2][3][4]




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Community Commentary

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Alleles, Strains, and Phenotypes

Complete Deletion

Genotype: RHY1202
Phenotype(s): Loss of function (Null), Recessive, Viable

Deletion of COD1/SPF1 prevents the degradation of Hmg2p from being regulated. [1] [5]




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References

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  1. ↑ 1.0 1.1 Cronin SR, et al. (2000) Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p. J Cell Biol 148(5):915-24 SGD PMID 10704442
  2. ↑ Cronin SR, et al. (2002) Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis. J Cell Biol 157(6):1017-28 SGD PMID 12058017
  3. ↑ Katrin K, et al. (2012) Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes. Mol Biol Cell () SGD PMID 22918956
  4. ↑ Suzuki C and Shimma YI (1999) P-type ATPase spf1 mutants show a novel resistance mechanism for the killer toxin SMKT. Mol Microbiol 32(4):813-23 SGD PMID 10361284
  5. ↑ submitted by Stephen R. Cronin on 2003-06-13

See Help:Categories on how to add the wiki page for this gene to a Category </protect>

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