Difference between revisions of "YGR252W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003484 YGR252W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''GCN5 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''GCN5 '' | ||
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''ADA4, SWI9'' | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''AAS104, ADA4, SWI9'' |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]] | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]] | ||
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr VII: | + | |nowrap| Chr VII:996869..998188 |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003484 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003484 | ||
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| − | '''Description of YGR252W:''' | + | '''Description of YGR252W:''' Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation<ref name='S000145695'>Charles GM, et al. (2011) Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress. Proc Natl Acad Sci U S A () {{SGDpaper|S000145695}} PMID 21673141</ref><ref name='S000074512'>Langer MR, et al. (2001) Mutational analysis of conserved residues in the GCN5 family of histone acetyltransferases. J Biol Chem 276(33):31321-31 {{SGDpaper|S000074512}} PMID 11397810</ref><ref name='S000150775'>Lanza AM, et al. (2012) Linking yeast Gcn5p catalytic function and gene regulation using a quantitative, graded dominant mutant approach. PLoS One 7(4):e36193 {{SGDpaper|S000150775}} PMID 22558379</ref><ref name='S000061032'>Sterner DE and Berger SL (2000) Acetylation of histones and transcription-related factors. Microbiol Mol Biol Rev 64(2):435-59 {{SGDpaper|S000061032}} PMID 10839822</ref><ref name='S000146226'>Tous C, et al. (2011) A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J 30(10):1953-64 {{SGDpaper|S000146226}} PMID 21478823</ref><ref name='S000124028'>VanDemark AP, et al. (2007) Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation. Mol Cell 27(5):817-28 |
| − | {{SGDpaper| | + | {{SGDpaper|S000124028}} PMID 17803945</ref> |
<br> | <br> | ||
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Latest revision as of 13:05, 11 September 2012
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| Systematic name | YGR252W |
| Gene name | GCN5 |
| Aliases | AAS104, ADA4, SWI9 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:996869..998188 |
| Primary SGDID | S000003484 |
Description of YGR252W: Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation[1][2][3][4][5][6]
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References
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- ↑ Charles GM, et al. (2011) Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress. Proc Natl Acad Sci U S A () SGD PMID 21673141
- ↑ Langer MR, et al. (2001) Mutational analysis of conserved residues in the GCN5 family of histone acetyltransferases. J Biol Chem 276(33):31321-31 SGD PMID 11397810
- ↑ Lanza AM, et al. (2012) Linking yeast Gcn5p catalytic function and gene regulation using a quantitative, graded dominant mutant approach. PLoS One 7(4):e36193 SGD PMID 22558379
- ↑ Sterner DE and Berger SL (2000) Acetylation of histones and transcription-related factors. Microbiol Mol Biol Rev 64(2):435-59 SGD PMID 10839822
- ↑ Tous C, et al. (2011) A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J 30(10):1953-64 SGD PMID 21478823
- ↑ VanDemark AP, et al. (2007) Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation. Mol Cell 27(5):817-28 SGD PMID 17803945
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