Difference between revisions of "YKL204W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001687 YKL204W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''EAP1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''EAP1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XI: | + | |nowrap| Chr XI:53704..55602 |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000001687 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000001687 | ||
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| − | '''Description of YKL204W:''' eIF4E-associated protein, | + | '''Description of YKL204W:''' eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade<ref name='S000150503'>Blewett NH and Goldstrohm AC (2012) An eIF4E-binding protein promotes mRNA decapping and is required for PUF repression. Mol Cell Biol () {{SGDpaper|S000150503}} PMID 22890846</ref><ref name='S000059777'>Chial HJ, et al. (2000) Yeast Eap1p, an eIF4E-associated protein, has a separate function involving genetic stability. Curr Biol 10(23):1519-22 {{SGDpaper|S000059777}} PMID 11114520</ref><ref name='S000043142'>Cosentino GP, et al. (2000) Eap1p, a novel eukaryotic translation initiation factor 4E-associated protein in Saccharomyces cerevisiae. Mol Cell Biol 20(13):4604-13 |
| − | {{SGDpaper| | + | {{SGDpaper|S000043142}} PMID 10848587</ref> |
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Latest revision as of 14:05, 28 August 2012
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| Systematic name | YKL204W |
| Gene name | EAP1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:53704..55602 |
| Primary SGDID | S000001687 |
Description of YKL204W: eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade[1][2][3]
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References
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- ↑ Blewett NH and Goldstrohm AC (2012) An eIF4E-binding protein promotes mRNA decapping and is required for PUF repression. Mol Cell Biol () SGD PMID 22890846
- ↑ Chial HJ, et al. (2000) Yeast Eap1p, an eIF4E-associated protein, has a separate function involving genetic stability. Curr Biol 10(23):1519-22 SGD PMID 11114520
- ↑ Cosentino GP, et al. (2000) Eap1p, a novel eukaryotic translation initiation factor 4E-associated protein in Saccharomyces cerevisiae. Mol Cell Biol 20(13):4604-13 SGD PMID 10848587
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