Difference between revisions of "YAL015C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000013 YAL015C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''NTG1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''NTG1 '' | ||
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''FUN33, SCR1'' | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''FUN33, SCR1, ogg2'' |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]] | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]] | ||
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr I: | + | |nowrap| Chr I:128102..126903 |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000013 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000013 | ||
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| − | '''Description of YAL015C:''' DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair | + | '''Description of YAL015C:''' DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication<ref name='S000044732'>Alseth I, et al. (1999) The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast. Mol Cell Biol 19(5):3779-87 {{SGDpaper|S000044732}} PMID 10207101</ref><ref name='S000113653'>Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 {{SGDpaper|S000113653}} PMID 16169922</ref><ref name='S000128441'>Griffiths LM, et al. (2009) Dynamic compartmentalization of base excision repair proteins in response to nuclear and mitochondrial oxidative stress. Mol Cell Biol 29(3):794-807 {{SGDpaper|S000128441}} PMID 19029246</ref><ref name='S000128687'>Hori A, et al. (2009) Reactive oxygen species regulate DNA copy number in isolated yeast mitochondria by triggering recombination-mediated replication. Nucleic Acids Res 37(3):749-61 {{SGDpaper|S000128687}} PMID 19074198</ref><ref name='S000074087'>Meadows KL, et al. (2003) Characterization of AP lyase activities of Saccharomyces cerevisiae Ntg1p and Ntg2p: implications for biological function. Nucleic Acids Res 31(19):5560-7 |
| − | {{SGDpaper| | + | {{SGDpaper|S000074087}} PMID 14500818</ref> |
<br> | <br> | ||
<br> | <br> | ||
Latest revision as of 13:05, 21 August 2012
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| Systematic name | YAL015C |
| Gene name | NTG1 |
| Aliases | FUN33, SCR1, ogg2 |
| Feature type | ORF, Verified |
| Coordinates | Chr I:128102..126903 |
| Primary SGDID | S000000013 |
Description of YAL015C: DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication[1][2][3][4][5]
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References
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- ↑ Alseth I, et al. (1999) The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast. Mol Cell Biol 19(5):3779-87 SGD PMID 10207101
- ↑ Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 SGD PMID 16169922
- ↑ Griffiths LM, et al. (2009) Dynamic compartmentalization of base excision repair proteins in response to nuclear and mitochondrial oxidative stress. Mol Cell Biol 29(3):794-807 SGD PMID 19029246
- ↑ Hori A, et al. (2009) Reactive oxygen species regulate DNA copy number in isolated yeast mitochondria by triggering recombination-mediated replication. Nucleic Acids Res 37(3):749-61 SGD PMID 19074198
- ↑ Meadows KL, et al. (2003) Characterization of AP lyase activities of Saccharomyces cerevisiae Ntg1p and Ntg2p: implications for biological function. Nucleic Acids Res 31(19):5560-7 SGD PMID 14500818
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