Difference between revisions of "YDR513W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YDR513W YDR513W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002921 YDR513W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''GRX2 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''GRX2 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr IV:1471009..1471440
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|nowrap| Chr IV:1471017..1471448
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000002921
 
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'''Description of {{PAGENAME}}:''' Cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress<ref name='S000069834'>Collinson EJ, et al. (2002) The yeast glutaredoxins are active as glutathione peroxidases. J Biol Chem 277(19):16712-7 {{SGDpaper|S000069834}} PMID 11875065</ref><ref name='S000056789'>Gan ZR, et al. (1990) Complete amino acid sequence of yeast thioltransferase (glutaredoxin). Biochem Biophys Res Commun 168(3):944-51 {{SGDpaper|S000056789}} PMID 2189409</ref><ref name='S000054906'>Draculic T, et al. (2000) A single glutaredoxin or thioredoxin gene is essential for viability in the yeast Saccharomyces cerevisiae. Mol Microbiol 36(5):1167-74 {{SGDpaper|S000054906}} PMID 10844700</ref><ref name='S000053996'>Luikenhuis S, et al. (1998) The yeast Saccharomyces cerevisiae contains two glutaredoxin genes that are required for protection against reactive oxygen species. Mol Biol Cell 9(5):1081-91 {{SGDpaper|S000053996}} PMID 9571241</ref><ref name='S000048888'>Rodriguez-Manzaneque MT, et al. (1999) Grx5 glutaredoxin plays a central role in protection against protein oxidative damage in Saccharomyces cerevisiae. Mol Cell Biol 19(12):8180-90 {{SGDpaper|S000048888}} PMID 10567543</ref><ref name='S000048077'>Grant CM, et al. (2000) Differential regulation of glutaredoxin gene expression in response to stress conditions in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 1490(1-2):33-42
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'''Description of YDR513W:''' Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication<ref name='S000113653'>Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 {{SGDpaper|S000113653}} PMID 16169922</ref><ref name='S000069834'>Collinson EJ, et al. (2002) The yeast glutaredoxins are active as glutathione peroxidases. J Biol Chem 277(19):16712-7 {{SGDpaper|S000069834}} PMID 11875065</ref><ref name='S000054906'>Draculic T, et al. (2000) A single glutaredoxin or thioredoxin gene is essential for viability in the yeast Saccharomyces cerevisiae. Mol Microbiol 36(5):1167-74 {{SGDpaper|S000054906}} PMID 10844700</ref><ref name='S000056789'>Gan ZR, et al. (1990) Complete amino acid sequence of yeast thioltransferase (glutaredoxin). Biochem Biophys Res Commun 168(3):944-51 {{SGDpaper|S000056789}} PMID 2189409</ref><ref name='S000048077'>Grant CM, et al. (2000) Differential regulation of glutaredoxin gene expression in response to stress conditions in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 1490(1-2):33-42 {{SGDpaper|S000048077}} PMID 10786615</ref><ref name='S000053996'>Luikenhuis S, et al. (1998) The yeast Saccharomyces cerevisiae contains two glutaredoxin genes that are required for protection against reactive oxygen species. Mol Biol Cell 9(5):1081-91 {{SGDpaper|S000053996}} PMID 9571241</ref><ref name='S000048888'>Rodriguez-Manzaneque MT, et al. (1999) Grx5 glutaredoxin plays a central role in protection against protein oxidative damage in Saccharomyces cerevisiae. Mol Cell Biol 19(12):8180-90
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==Community Commentary==
 
==Community Commentary==
 
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 13:05, 16 August 2012

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Systematic name YDR513W
Gene name GRX2
Aliases TTR1
Feature type ORF, Verified
Coordinates Chr IV:1471017..1471448
Primary SGDID S000002921


Description of YDR513W: Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication[1][2][3][4][5][6][7]




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Community Commentary

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References

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  1. ↑ Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 SGD PMID 16169922
  2. ↑ Collinson EJ, et al. (2002) The yeast glutaredoxins are active as glutathione peroxidases. J Biol Chem 277(19):16712-7 SGD PMID 11875065
  3. ↑ Draculic T, et al. (2000) A single glutaredoxin or thioredoxin gene is essential for viability in the yeast Saccharomyces cerevisiae. Mol Microbiol 36(5):1167-74 SGD PMID 10844700
  4. ↑ Gan ZR, et al. (1990) Complete amino acid sequence of yeast thioltransferase (glutaredoxin). Biochem Biophys Res Commun 168(3):944-51 SGD PMID 2189409
  5. ↑ Grant CM, et al. (2000) Differential regulation of glutaredoxin gene expression in response to stress conditions in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 1490(1-2):33-42 SGD PMID 10786615
  6. ↑ Luikenhuis S, et al. (1998) The yeast Saccharomyces cerevisiae contains two glutaredoxin genes that are required for protection against reactive oxygen species. Mol Biol Cell 9(5):1081-91 SGD PMID 9571241
  7. ↑ Rodriguez-Manzaneque MT, et al. (1999) Grx5 glutaredoxin plays a central role in protection against protein oxidative damage in Saccharomyces cerevisiae. Mol Cell Biol 19(12):8180-90 SGD PMID 10567543

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