Difference between revisions of "YBR136W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000340 YBR136W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MEC1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MEC1 '' | ||
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''ESR1, SAD3'' | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''ESR1, RAD31, SAD3'' |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]] | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]] | ||
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr II: | + | |nowrap| Chr II:505668..512774 |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000340 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000340 | ||
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| − | '''Description of YBR136W:''' Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination<ref name='S000039357'>Grushcow JM, et al. (1999) Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice. Genetics 153(2):607-20 {{SGDpaper|S000039357}} PMID 10511543</ref><ref name='S000042917'>Kato R and Ogawa H (1994) An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res 22(15):3104-12 {{SGDpaper|S000042917}} PMID 8065923 | + | '''Description of YBR136W:''' Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres<ref name='S000057992'>Elledge SJ (1996) Cell cycle checkpoints: preventing an identity crisis. Science 274(5293):1664-72 {{SGDpaper|S000057992}} PMID 8939848</ref><ref name='S000039357'>Grushcow JM, et al. (1999) Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice. Genetics 153(2):607-20 {{SGDpaper|S000039357}} PMID 10511543</ref><ref name='S000148240'>Hector RE, et al. (2012) Mec1p associates with functionally compromised telomeres. Chromosoma () {{SGDpaper|S000148240}} PMID 22289863</ref><ref name='S000042917'>Kato R and Ogawa H (1994) An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res 22(15):3104-12 {{SGDpaper|S000042917}} PMID 8065923</ref><ref name='S000057903'>Kiser GL and Weinert TA (1996) Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function. Mol Biol Cell 7(5):703-18 {{SGDpaper|S000057903}} PMID 8744945</ref><ref name='S000150401'>Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.LID - 10.1038/ncb2549 [doi] Nat Cell Biol () {{SGDpaper|S000150401}} PMID 22842922</ref><ref name='S000058330'>Weinert T (1998) DNA damage checkpoints update: getting molecular. Curr Opin Genet Dev 8(2):185-93 {{SGDpaper|S000058330}} PMID 9610409</ref><ref name='S000054274'>Weinert TA, et al. (1994) Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev 8(6):652-65 |
| − | {{SGDpaper| | + | {{SGDpaper|S000054274}} PMID 7926756</ref> |
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<br> | <br> | ||
Latest revision as of 13:05, 16 August 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YBR136W |
| Gene name | MEC1 |
| Aliases | ESR1, RAD31, SAD3 |
| Feature type | ORF, Verified |
| Coordinates | Chr II:505668..512774 |
| Primary SGDID | S000000340 |
Description of YBR136W: Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres[1][2][3][4][5][6][7][8]
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Contents
Community Commentary
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References
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- ↑ Elledge SJ (1996) Cell cycle checkpoints: preventing an identity crisis. Science 274(5293):1664-72 SGD PMID 8939848
- ↑ Grushcow JM, et al. (1999) Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice. Genetics 153(2):607-20 SGD PMID 10511543
- ↑ Hector RE, et al. (2012) Mec1p associates with functionally compromised telomeres. Chromosoma () SGD PMID 22289863
- ↑ Kato R and Ogawa H (1994) An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res 22(15):3104-12 SGD PMID 8065923
- ↑ Kiser GL and Weinert TA (1996) Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function. Mol Biol Cell 7(5):703-18 SGD PMID 8744945
- ↑ Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.LID - 10.1038/ncb2549 [doi] Nat Cell Biol () SGD PMID 22842922
- ↑ Weinert T (1998) DNA damage checkpoints update: getting molecular. Curr Opin Genet Dev 8(2):185-93 SGD PMID 9610409
- ↑ Weinert TA, et al. (1994) Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev 8(6):652-65 SGD PMID 7926756
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