Difference between revisions of "YGR280C"
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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Revision as of 12:02, 21 February 2007
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| Systematic name | YGR280C |
| Gene name | PXR1 |
| Aliases | GNO1 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:1051731..1050916 |
Description of YGR280C: Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain[1][2][3]
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References
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- ↑ Lin J and Blackburn EH (2004) Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA. Genes Dev 18(4):387-96 SGD PMID 14977919
- ↑ Guglielmi B and Werner M (2002) The yeast homolog of human PinX1 is involved in rRNA and small nucleolar RNA maturation, not in telomere elongation inhibition. J Biol Chem 277(38):35712-9 SGD PMID 12107183
- ↑ Zhou XZ and Lu KP (2001) The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 107(3):347-59 SGD PMID 11701125
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