Difference between revisions of "YOR098C"
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| − | '''Description of YOR098C:''' | + | '''Description of YOR098C:''' FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153<ref name='S000040743'>Bogerd AM, et al. (1994) nup1 mutants exhibit pleiotropic defects in nuclear pore complex function. J Cell Biol 127(2):319-32 {{SGDpaper|S000040743}} PMID 7929578</ref><ref name='S000051060'>Davis LI and Fink GR (1990) The NUP1 gene encodes an essential component of the yeast nuclear pore complex. Cell 61(6):965-78 {{SGDpaper|S000051060}} PMID 2190694</ref><ref name='S000069856'>Gilchrist D, et al. (2002) Accelerating the rate of disassembly of karyopherin.cargo complexes. J Biol Chem 277(20):18161-72 {{SGDpaper|S000069856}} PMID 11867631</ref><ref name='S000122438'>Patel SS, et al. (2007) Natively unfolded nucleoporins gate protein diffusion across the nuclear pore complex. Cell 129(1):83-96 {{SGDpaper|S000122438}} PMID 17418788</ref><ref name='S000075312'>Pyhtila B and Rexach M (2003) A gradient of affinity for the karyopherin Kap95p along the yeast nuclear pore complex. J Biol Chem 278(43):42699-709 {{SGDpaper|S000075312}} PMID 12917401</ref><ref name='S000059349'>Stage-Zimmermann T, et al. (2000) Factors affecting nuclear export of the 60S ribosomal subunit in vivo. Mol Biol Cell 11(11):3777-89 {{SGDpaper|S000059349}} PMID 11071906</ref><ref name='S000075845'>Strawn LA, et al. (2004) Minimal nuclear pore complexes define FG repeat domains essential for transport. Nat Cell Biol 6(3):197-206 {{SGDpaper|S000075845}} PMID 15039779</ref><ref name='S000049646'>Titov AA and Blobel G (1999) The karyopherin Kap122p/Pdr6p imports both subunits of the transcription factor IIA into the nucleus. J Cell Biol 147(2):235-46 |
| − | {{SGDpaper| | + | {{SGDpaper|S000049646}} PMID 10525531</ref> |
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Latest revision as of 13:05, 19 June 2012
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| Systematic name | YOR098C |
| Gene name | NUP1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:511178..507948 |
| Primary SGDID | S000005624 |
Description of YOR098C: FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153[1][2][3][4][5][6][7][8]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [9] [10]
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References
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- ↑ Bogerd AM, et al. (1994) nup1 mutants exhibit pleiotropic defects in nuclear pore complex function. J Cell Biol 127(2):319-32 SGD PMID 7929578
- ↑ Davis LI and Fink GR (1990) The NUP1 gene encodes an essential component of the yeast nuclear pore complex. Cell 61(6):965-78 SGD PMID 2190694
- ↑ Gilchrist D, et al. (2002) Accelerating the rate of disassembly of karyopherin.cargo complexes. J Biol Chem 277(20):18161-72 SGD PMID 11867631
- ↑ Patel SS, et al. (2007) Natively unfolded nucleoporins gate protein diffusion across the nuclear pore complex. Cell 129(1):83-96 SGD PMID 17418788
- ↑ Pyhtila B and Rexach M (2003) A gradient of affinity for the karyopherin Kap95p along the yeast nuclear pore complex. J Biol Chem 278(43):42699-709 SGD PMID 12917401
- ↑ Stage-Zimmermann T, et al. (2000) Factors affecting nuclear export of the 60S ribosomal subunit in vivo. Mol Biol Cell 11(11):3777-89 SGD PMID 11071906
- ↑ Strawn LA, et al. (2004) Minimal nuclear pore complexes define FG repeat domains essential for transport. Nat Cell Biol 6(3):197-206 SGD PMID 15039779
- ↑ Titov AA and Blobel G (1999) The karyopherin Kap122p/Pdr6p imports both subunits of the transcription factor IIA into the nucleus. J Cell Biol 147(2):235-46 SGD PMID 10525531
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-29
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