Difference between revisions of "YMR228W"

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{|{{Prettytable}} align = 'right' width = '200px'
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YMR228W YMR228W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004841 YMR228W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''MTF1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''MTF1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr XIII:724625..725650
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|nowrap| Chr XIII:724626..725651
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000004841
 
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'''Description of {{PAGENAME}}:''' Mitochondrial RNA polymerase specificity factor with structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors, interacts with mitochondrial core polymerase Rpo41p<ref name='S000079841'>Matsunaga M and Jaehning JA (2004) Intrinsic promoter recognition by a &quot;core&quot; RNA polymerase. J Biol Chem 279(43):44239-42 {{SGDpaper|S000079841}} PMID 15342628</ref><ref name='S000067659'>Schubot FD, et al. (2001) Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription. Protein Sci 10(10):1980-8 {{SGDpaper|S000067659}} PMID 11567089</ref><ref name='S000039346'>Mangus DA, et al. (1994) Release of the yeast mitochondrial RNA polymerase specificity factor from transcription complexes. J Biol Chem 269(42):26568-74
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'''Description of YMR228W:''' Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation<ref name='S000039346'>Mangus DA, et al. (1994) Release of the yeast mitochondrial RNA polymerase specificity factor from transcription complexes. J Biol Chem 269(42):26568-74 {{SGDpaper|S000039346}} PMID 7929382</ref><ref name='S000079841'>Matsunaga M and Jaehning JA (2004) Intrinsic promoter recognition by a core RNA polymerase. J Biol Chem 279(43):44239-42 {{SGDpaper|S000079841}} PMID 15342628</ref><ref name='S000067659'>Schubot FD, et al. (2001) Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription. Protein Sci 10(10):1980-8 {{SGDpaper|S000067659}} PMID 11567089</ref><ref name='S000146745'>Tang GQ, et al. (2011) Transcription factor-dependent DNA bending governs promoter recognition by the mitochondrial RNA polymerase. J Biol Chem () {{SGDpaper|S000146745}} PMID 21911502</ref><ref name='S000149299'>Velazquez G, et al. (2012) Conservation of Promoter Melting Mechanisms in Divergent Regions of the Single-Subunit RNA Polymerases. Biochemistry ()
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  {{SGDpaper|S000039346}} PMID 7929382</ref>
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  {{SGDpaper|S000149299}} PMID 22524540</ref>
 
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==Community Commentary==
 
==Community Commentary==
 
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<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
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<!--
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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Latest revision as of 13:05, 9 May 2012

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Systematic name YMR228W
Gene name MTF1
Aliases
Feature type ORF, Verified
Coordinates Chr XIII:724626..725651
Primary SGDID S000004841


Description of YMR228W: Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation[1][2][3][4][5]




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Community Commentary

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References

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  1. ↑ Mangus DA, et al. (1994) Release of the yeast mitochondrial RNA polymerase specificity factor from transcription complexes. J Biol Chem 269(42):26568-74 SGD PMID 7929382
  2. ↑ Matsunaga M and Jaehning JA (2004) Intrinsic promoter recognition by a core RNA polymerase. J Biol Chem 279(43):44239-42 SGD PMID 15342628
  3. ↑ Schubot FD, et al. (2001) Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription. Protein Sci 10(10):1980-8 SGD PMID 11567089
  4. ↑ Tang GQ, et al. (2011) Transcription factor-dependent DNA bending governs promoter recognition by the mitochondrial RNA polymerase. J Biol Chem () SGD PMID 21911502
  5. ↑ Velazquez G, et al. (2012) Conservation of Promoter Melting Mechanisms in Divergent Regions of the Single-Subunit RNA Polymerases. Biochemistry () SGD PMID 22524540

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