Difference between revisions of "YER159C"

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'''Description of {{PAGENAME}}:''' Protein that forms a heterodimeric histone-fold NC2 general transcription regulator complex with Ydr1p that binds to TBP and represses RNA pol II transcription during assembly of the preinitiation complex, homologous to human NC2alpha<ref name='S000078394'>Cang Y and Prelich G (2002) Direct stimulation of transcription by negative cofactor 2 (NC2) through TATA-binding protein (TBP). Proc Natl Acad Sci U S A 99(20):12727-32 {{SGDpaper|S000078394}} PMID 12237409</ref><ref name='S000073385'>Estruch F and Cole CN (2003) An early function during transcription for the yeast mRNA export factor Dbp5p/Rat8p suggested by its genetic and physical interactions with transcription factor IIH components. Mol Biol Cell 14(4):1664-76 {{SGDpaper|S000073385}} PMID 12686617</ref><ref name='S000057997'>Goppelt A and Meisterernst M (1996) Characterization of the basal inhibitor of class II transcription NC2 from Saccharomyces cerevisiae. Nucleic Acids Res 24(22):4450-5 {{SGDpaper|S000057997}} PMID 8948634</ref><ref name='S000048426'>Kim S, et al. (1997) The Dr1/DRAP1 heterodimer is a global repressor of transcription in vivo. Proc Natl Acad Sci U S A 94(3):820-5
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'''Description of {{PAGENAME}}:''' Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha<ref name='S000078394'>Cang Y and Prelich G (2002) Direct stimulation of transcription by negative cofactor 2 (NC2) through TATA-binding protein (TBP). Proc Natl Acad Sci U S A 99(20):12727-32 {{SGDpaper|S000078394}} PMID 12237409</ref><ref name='S000073385'>Estruch F and Cole CN (2003) An early function during transcription for the yeast mRNA export factor Dbp5p/Rat8p suggested by its genetic and physical interactions with transcription factor IIH components. Mol Biol Cell 14(4):1664-76 {{SGDpaper|S000073385}} PMID 12686617</ref><ref name='S000057997'>Goppelt A and Meisterernst M (1996) Characterization of the basal inhibitor of class II transcription NC2 from Saccharomyces cerevisiae. Nucleic Acids Res 24(22):4450-5 {{SGDpaper|S000057997}} PMID 8948634</ref><ref name='S000048426'>Kim S, et al. (1997) The Dr1/DRAP1 heterodimer is a global repressor of transcription in vivo. Proc Natl Acad Sci U S A 94(3):820-5
 
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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Revision as of 13:02, 21 February 2007

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Systematic name YER159C
Gene name BUR6
Aliases NCB1
Feature type ORF, Verified
Coordinates Chr V:491953..491525


Description of YER159C: Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha[1][2][3][4]




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References

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  1. Cang Y and Prelich G (2002) Direct stimulation of transcription by negative cofactor 2 (NC2) through TATA-binding protein (TBP). Proc Natl Acad Sci U S A 99(20):12727-32 SGD PMID 12237409
  2. Estruch F and Cole CN (2003) An early function during transcription for the yeast mRNA export factor Dbp5p/Rat8p suggested by its genetic and physical interactions with transcription factor IIH components. Mol Biol Cell 14(4):1664-76 SGD PMID 12686617
  3. Goppelt A and Meisterernst M (1996) Characterization of the basal inhibitor of class II transcription NC2 from Saccharomyces cerevisiae. Nucleic Acids Res 24(22):4450-5 SGD PMID 8948634
  4. Kim S, et al. (1997) The Dr1/DRAP1 heterodimer is a global repressor of transcription in vivo. Proc Natl Acad Sci U S A 94(3):820-5 SGD PMID 9023340

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