Difference between revisions of "YDR440W"
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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Revision as of 12:02, 21 February 2007
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| Systematic name | YDR440W |
| Gene name | DOT1 |
| Aliases | PCH1 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:1342485..1344233 |
Description of YDR440W: Nucleosomal histone H3-Lys79 methylase, associates with transcriptionally active genes, functions in gene silencing at telomeres, most likely by directly modulating chromatin structure and Sir protein localization[1][2][3]
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Contents
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References
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- ↑ Ng HH, et al. (2003) The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B. J Biol Chem 278(36):33625-8 SGD PMID 12876293
- ↑ Lacoste N, et al. (2002) Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase. J Biol Chem 277(34):30421-4 SGD PMID 12097318
- ↑ Ng HH, et al. (2002) Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association. Genes Dev 16(12):1518-27 SGD PMID 12080090
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