Difference between revisions of "YPR129W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000006333 YPR129W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000006333 YPR129W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SCD6 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SCD6 ''
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'''Description of YPR129W:''' Protein containing an Lsm domain; negatively regulates translation initiation via 48S preinitiation complex assembly; may bind RNA and have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1<ref name='S000076596'>Albrecht M and Lengauer T (2004) Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. FEBS Lett 569(1-3):18-26 {{SGDpaper|S000076596}} PMID 15225602</ref><ref name='S000053738'>Nelson KK and Lemmon SK (1993) Suppressors of clathrin deficiency: overexpression of ubiquitin rescues lethal strains of clathrin-deficient Saccharomyces cerevisiae. Mol Cell Biol 13(1):521-32
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'''Description of YPR129W:''' Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1<ref name='S000076596'>Albrecht M and Lengauer T (2004) Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. FEBS Lett 569(1-3):18-26 {{SGDpaper|S000076596}} PMID 15225602</ref><ref name='S000053738'>Nelson KK and Lemmon SK (1993) Suppressors of clathrin deficiency: overexpression of ubiquitin rescues lethal strains of clathrin-deficient Saccharomyces cerevisiae. Mol Cell Biol 13(1):521-32 {{SGDpaper|S000053738}} PMID 8380227</ref><ref name='S000148260'>Rajyaguru P, et al. (2012) Scd6 Targets eIF4G to Repress Translation: RGG Motif Proteins as a Class of eIF4G-Binding Proteins. Mol Cell 45(2):244-54
  {{SGDpaper|S000053738}} PMID 8380227</ref>
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  {{SGDpaper|S000148260}} PMID 22284680</ref>
 
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Latest revision as of 13:05, 19 March 2012

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Systematic name YPR129W
Gene name SCD6
Aliases LSM13
Feature type ORF, Verified
Coordinates Chr XVI:792687..793736
Primary SGDID S000006333


Description of YPR129W: Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1[1][2][3]




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References

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  1. Albrecht M and Lengauer T (2004) Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. FEBS Lett 569(1-3):18-26 SGD PMID 15225602
  2. Nelson KK and Lemmon SK (1993) Suppressors of clathrin deficiency: overexpression of ubiquitin rescues lethal strains of clathrin-deficient Saccharomyces cerevisiae. Mol Cell Biol 13(1):521-32 SGD PMID 8380227
  3. Rajyaguru P, et al. (2012) Scd6 Targets eIF4G to Repress Translation: RGG Motif Proteins as a Class of eIF4G-Binding Proteins. Mol Cell 45(2):244-54 SGD PMID 22284680

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