Difference between revisions of "YHR205W"
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| − | '''Description of YHR205W:''' | + | '''Description of YHR205W:''' AGC family protein kinase and functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan<ref name='S000041292'>Crauwels M, et al. (1997) The Sch9 protein kinase in the yeast Saccharomyces cerevisiae controls cAPK activity and is required for nitrogen activation of the fermentable-growth-medium-induced (FGM) pathway. Microbiology 143 ( Pt 8)():2627-37 {{SGDpaper|S000041292}} PMID 9274016</ref><ref name='S000060129'>Fabrizio P, et al. (2001) Regulation of longevity and stress resistance by Sch9 in yeast. Science 292(5515):288-90 {{SGDpaper|S000060129}} PMID 11292860</ref><ref name='S000148286'>Huang X, et al. (2012) Down-regulating sphingolipid synthesis increases yeast lifespan. PLoS Genet 8(2):e1002493 {{SGDpaper|S000148286}} PMID 22319457</ref><ref name='S000053948'>Morano KA and Thiele DJ (1999) The Sch9 protein kinase regulates Hsp90 chaperone complex signal transduction activity in vivo. EMBO J 18(21):5953-62 {{SGDpaper|S000053948}} PMID 10545107</ref><ref name='S000123014'>Pascual-Ahuir A and Proft M (2007) The Sch9 kinase is a chromatin-associated transcriptional activator of osmostress-responsive genes. EMBO J 26(13):3098-108 {{SGDpaper|S000123014}} PMID 17568771</ref><ref name='S000077579'>Prusty R and Keil RL (2004) SCH9, a putative protein kinase from Saccharomyces cerevisiae, affects HOT1-stimulated recombination. Mol Genet Genomics 272(3):264-74 {{SGDpaper|S000077579}} PMID 15349770</ref><ref name='S000123000'>Urban J, et al. (2007) Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol Cell 26(5):663-74 {{SGDpaper|S000123000}} PMID 17560372</ref><ref name='S000049948'>di Blasi F, et al. (1993) The SCH9 protein kinase mRNA contains a long 5' leader with a small open reading frame. Yeast 9(1):21-32 |
{{SGDpaper|S000049948}} PMID 8442384</ref> | {{SGDpaper|S000049948}} PMID 8442384</ref> | ||
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Latest revision as of 13:05, 13 March 2012
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| Systematic name | YHR205W |
| Gene name | SCH9 |
| Aliases | HRM2, KOM1 |
| Feature type | ORF, Verified |
| Coordinates | Chr VIII:509363..511837 |
| Primary SGDID | S000001248 |
Description of YHR205W: AGC family protein kinase and functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan[1][2][3][4][5][6][7][8]
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References
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- ↑ Crauwels M, et al. (1997) The Sch9 protein kinase in the yeast Saccharomyces cerevisiae controls cAPK activity and is required for nitrogen activation of the fermentable-growth-medium-induced (FGM) pathway. Microbiology 143 ( Pt 8)():2627-37 SGD PMID 9274016
- ↑ Fabrizio P, et al. (2001) Regulation of longevity and stress resistance by Sch9 in yeast. Science 292(5515):288-90 SGD PMID 11292860
- ↑ Huang X, et al. (2012) Down-regulating sphingolipid synthesis increases yeast lifespan. PLoS Genet 8(2):e1002493 SGD PMID 22319457
- ↑ Morano KA and Thiele DJ (1999) The Sch9 protein kinase regulates Hsp90 chaperone complex signal transduction activity in vivo. EMBO J 18(21):5953-62 SGD PMID 10545107
- ↑ Pascual-Ahuir A and Proft M (2007) The Sch9 kinase is a chromatin-associated transcriptional activator of osmostress-responsive genes. EMBO J 26(13):3098-108 SGD PMID 17568771
- ↑ Prusty R and Keil RL (2004) SCH9, a putative protein kinase from Saccharomyces cerevisiae, affects HOT1-stimulated recombination. Mol Genet Genomics 272(3):264-74 SGD PMID 15349770
- ↑ Urban J, et al. (2007) Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol Cell 26(5):663-74 SGD PMID 17560372
- ↑ di Blasi F, et al. (1993) The SCH9 protein kinase mRNA contains a long 5' leader with a small open reading frame. Yeast 9(1):21-32 SGD PMID 8442384
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