Difference between revisions of "YNL183C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005127 YNL183C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''NPR1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''NPR1 '' | ||
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| − | '''Description of YNL183C:''' Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p<ref name='S000066226'>De Craene JO, et al. (2001) The Npr1 kinase controls biosynthetic and endocytic sorting of the yeast Gap1 permease. J Biol Chem 276(47):43939-48 {{SGDpaper|S000066226}} PMID 11500493</ref><ref name='S000136012'>O'Donnell AF, et al. (2010) {alpha}-Arrestins Aly1 and Aly2 Regulate Intracellular Trafficking in Response to Nutrient Signaling. Mol Biol Cell 21(20):3552-66 | + | '''Description of YNL183C:''' Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex<ref name='S000066226'>De Craene JO, et al. (2001) The Npr1 kinase controls biosynthetic and endocytic sorting of the yeast Gap1 permease. J Biol Chem 276(47):43939-48 {{SGDpaper|S000066226}} PMID 11500493</ref><ref name='S000148186'>MacGurn JA, et al. (2011) TORC1 regulates endocytosis via Npr1-mediated phosphoinhibition of a ubiquitin ligase adaptor. Cell 147(5):1104-17 {{SGDpaper|S000148186}} PMID 22118465</ref><ref name='S000136012'>O'Donnell AF, et al. (2010) {alpha}-Arrestins Aly1 and Aly2 Regulate Intracellular Trafficking in Response to Nutrient Signaling. Mol Biol Cell 21(20):3552-66 {{SGDpaper|S000136012}} PMID 20739461</ref><ref name='S000047818'>Schmidt A, et al. (1998) The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease. EMBO J 17(23):6924-31 |
| − | {{SGDpaper| | + | {{SGDpaper|S000047818}} PMID 9843498</ref> |
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Latest revision as of 13:05, 2 March 2012
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| Systematic name | YNL183C |
| Gene name | NPR1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:295509..293137 |
| Primary SGDID | S000005127 |
Description of YNL183C: Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex[1][2][3][4]
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References
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- ↑ De Craene JO, et al. (2001) The Npr1 kinase controls biosynthetic and endocytic sorting of the yeast Gap1 permease. J Biol Chem 276(47):43939-48 SGD PMID 11500493
- ↑ MacGurn JA, et al. (2011) TORC1 regulates endocytosis via Npr1-mediated phosphoinhibition of a ubiquitin ligase adaptor. Cell 147(5):1104-17 SGD PMID 22118465
- ↑ O'Donnell AF, et al. (2010) {alpha}-Arrestins Aly1 and Aly2 Regulate Intracellular Trafficking in Response to Nutrient Signaling. Mol Biol Cell 21(20):3552-66 SGD PMID 20739461
- ↑ Schmidt A, et al. (1998) The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease. EMBO J 17(23):6924-31 SGD PMID 9843498
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