Difference between revisions of "YNR018W"
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| − | '''Description of YNR018W:''' | + | '''Description of YNR018W:''' Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast<ref name='S000131554'>Helbig AO, et al. (2009) A three-way proteomics strategy allows differential analysis of yeast mitochondrial membrane protein complexes under anaerobic and aerobic conditions. Proteomics 9(20):4787-98 {{SGDpaper|S000131554}} PMID 19750512</ref><ref name='S000148283'>Strogolova V, et al. (2012) Rcf1 and Rcf2, members of the hypoxia induced gene 1 protein family, are critical components of the mitochondrial cytochrome bc1-cytochrome c oxidase supercomplex. Mol Cell Biol () {{SGDpaper|S000148283}} PMID 22310663</ref><ref name='S000148432'>Vukotic M, et al. (2012) Rcf1 Mediates Cytochrome Oxidase Assembly and Respirasome Formation, Revealing Heterogeneity of the Enzyme Complex. Cell Metab () |
| − | {{SGDpaper| | + | {{SGDpaper|S000148432}} PMID 22342701</ref> |
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Latest revision as of 13:05, 22 February 2012
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| Systematic name | YNR018W |
| Gene name | RCF2 |
| Aliases | AIM38 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:664270..664944 |
| Primary SGDID | S000005301 |
Description of YNR018W: Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast[1][2][3]
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References
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- ↑ Helbig AO, et al. (2009) A three-way proteomics strategy allows differential analysis of yeast mitochondrial membrane protein complexes under anaerobic and aerobic conditions. Proteomics 9(20):4787-98 SGD PMID 19750512
- ↑ Strogolova V, et al. (2012) Rcf1 and Rcf2, members of the hypoxia induced gene 1 protein family, are critical components of the mitochondrial cytochrome bc1-cytochrome c oxidase supercomplex. Mol Cell Biol () SGD PMID 22310663
- ↑ Vukotic M, et al. (2012) Rcf1 Mediates Cytochrome Oxidase Assembly and Respirasome Formation, Revealing Heterogeneity of the Enzyme Complex. Cell Metab () SGD PMID 22342701
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