Difference between revisions of "YER068W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000870 YER068W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MOT2 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MOT2 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr V: | + | |nowrap| Chr V:293050..294813 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000870 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000870 | ||
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| − | '''Description of YER068W:''' | + | '''Description of YER068W:''' Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications<ref name='S000062056'>Badarinarayana V, et al. (2000) Functional interaction of CCR4-NOT proteins with TATAA-binding protein (TBP) and its associated factors in yeast. Genetics 155(3):1045-54 {{SGDpaper|S000062056}} PMID 10880468</ref><ref name='S000042122'>Bai Y, et al. (1999) The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and functionally separated from NOT2, NOT4, and NOT5. Mol Cell Biol 19(10):6642-51 {{SGDpaper|S000042122}} PMID 10490603</ref><ref name='S000074806'>Denis CL, et al. (2001) Genetic evidence supports a role for the yeast CCR4-NOT complex in transcriptional elongation. Genetics 158(2):627-34 {{SGDpaper|S000074806}} PMID 11404327</ref><ref name='S000049134'>Liu HY, et al. (1998) The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively. EMBO J 17(4):1096-106 {{SGDpaper|S000049134}} PMID 9463387</ref><ref name='S000129902'>Mersman DP, et al. (2009) Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression. Genes Dev 23(8):951-62 {{SGDpaper|S000129902}} PMID 19346402</ref><ref name='S000118045'>Panasenko O, et al. (2006) The yeast Ccr4-Not complex controls ubiquitination of the nascent-associated polypeptide (NAC-EGD) complex. J Biol Chem 281(42):31389-98 |
| − | {{SGDpaper| | + | {{SGDpaper|S000118045}} PMID 16926149</ref> |
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Latest revision as of 13:05, 16 February 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YER068W |
| Gene name | MOT2 |
| Aliases | NOT4, SIG1 |
| Feature type | ORF, Verified |
| Coordinates | Chr V:293050..294813 |
| Primary SGDID | S000000870 |
Description of YER068W: Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications[1][2][3][4][5][6]
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References
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- ↑ Badarinarayana V, et al. (2000) Functional interaction of CCR4-NOT proteins with TATAA-binding protein (TBP) and its associated factors in yeast. Genetics 155(3):1045-54 SGD PMID 10880468
- ↑ Bai Y, et al. (1999) The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and functionally separated from NOT2, NOT4, and NOT5. Mol Cell Biol 19(10):6642-51 SGD PMID 10490603
- ↑ Denis CL, et al. (2001) Genetic evidence supports a role for the yeast CCR4-NOT complex in transcriptional elongation. Genetics 158(2):627-34 SGD PMID 11404327
- ↑ Liu HY, et al. (1998) The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively. EMBO J 17(4):1096-106 SGD PMID 9463387
- ↑ Mersman DP, et al. (2009) Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression. Genes Dev 23(8):951-62 SGD PMID 19346402
- ↑ Panasenko O, et al. (2006) The yeast Ccr4-Not complex controls ubiquitination of the nascent-associated polypeptide (NAC-EGD) complex. J Biol Chem 281(42):31389-98 SGD PMID 16926149
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