Difference between revisions of "YDR146C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002553 YDR146C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SWI5 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SWI5 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr IV: | + | |nowrap| Chr IV:750742..748613 |
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000002553 | ||
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| − | '''Description of | + | '''Description of YDR146C:''' Transcription factor that recruits the Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase<ref name='S000065881'>Bhoite LT, et al. (2001) The Swi5 activator recruits the Mediator complex to the HO promoter without RNA polymerase II. Genes Dev 15(18):2457-69 {{SGDpaper|S000065881}} PMID 11562354</ref><ref name='S000043669'>Cosma MP, et al. (1999) Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter. Cell 97(3):299-311 {{SGDpaper|S000043669}} PMID 10319811</ref><ref name='S000054707'>Dohrmann PR, et al. (1992) Parallel pathways of gene regulation: homologous regulators SWI5 and ACE2 differentially control transcription of HO and chitinase. Genes Dev 6(1):93-104 {{SGDpaper|S000054707}} PMID 1730413</ref><ref name='S000044727'>McBride HJ, et al. (1999) Distinct regions of the Swi5 and Ace2 transcription factors are required for specific gene activation. J Biol Chem 274(30):21029-36 {{SGDpaper|S000044727}} PMID 10409653</ref><ref name='S000041330'>Moll T, et al. (1991) The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5. Cell 66(4):743-58 {{SGDpaper|S000041330}} PMID 1652372</ref><ref name='S000054843'>Stern M, et al. (1984) Five SWI genes are required for expression of the HO gene in yeast. J Mol Biol 178(4):853-68 {{SGDpaper|S000054843}} PMID 6436497</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 |
| − | {{SGDpaper| | + | {{SGDpaper|S000074306}} PMID 14574415</ref> |
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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Latest revision as of 13:05, 3 February 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YDR146C |
| Gene name | SWI5 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:750742..748613 |
| Primary SGDID | S000002553 |
Description of YDR146C: Transcription factor that recruits the Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase[1][2][3][4][5][6][7]
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Community Commentary
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [7] [8]
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References
See Help:References on how to add references
- ↑ Bhoite LT, et al. (2001) The Swi5 activator recruits the Mediator complex to the HO promoter without RNA polymerase II. Genes Dev 15(18):2457-69 SGD PMID 11562354
- ↑ Cosma MP, et al. (1999) Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter. Cell 97(3):299-311 SGD PMID 10319811
- ↑ Dohrmann PR, et al. (1992) Parallel pathways of gene regulation: homologous regulators SWI5 and ACE2 differentially control transcription of HO and chitinase. Genes Dev 6(1):93-104 SGD PMID 1730413
- ↑ McBride HJ, et al. (1999) Distinct regions of the Swi5 and Ace2 transcription factors are required for specific gene activation. J Biol Chem 274(30):21029-36 SGD PMID 10409653
- ↑ Moll T, et al. (1991) The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5. Cell 66(4):743-58 SGD PMID 1652372
- ↑ Stern M, et al. (1984) Five SWI genes are required for expression of the HO gene in yeast. J Mol Biol 178(4):853-68 SGD PMID 6436497
- ↑ 7.0 7.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
SGD PMID 14574415 Cite error: Invalid
<ref>tag; name "S000074306" defined multiple times with different content - ↑ submitted by Jeff Ubersax on 2004-01-21
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
