Difference between revisions of "YPR200C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000006404 YPR200C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''ARR2 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''ARR2 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XVI: | + | |nowrap| Chr XVI:939671..939279 |
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000006404 | ||
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| − | '''Description of | + | '''Description of YPR200C:''' Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p<ref name='S000058383'>Mukhopadhyay R and Rosen BP (1998) Saccharomyces cerevisiae ACR2 gene encodes an arsenate reductase. FEMS Microbiol Lett 168(1):127-36 {{SGDpaper|S000058383}} PMID 9812373</ref><ref name='S000054698'>Mukhopadhyay R, et al. (2000) Purification and characterization of ACR2p, the Saccharomyces cerevisiae arsenate reductase. J Biol Chem 275(28):21149-57 |
{{SGDpaper|S000054698}} PMID 10801893</ref> | {{SGDpaper|S000054698}} PMID 10801893</ref> | ||
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| + | <!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation --> | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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Latest revision as of 06:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YPR200C |
| Gene name | ARR2 |
| Aliases | ACR2 |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:939671..939279 |
| Primary SGDID | S000006404 |
Description of YPR200C: Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p[1][2]
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Contents
Community Commentary
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Other
Other
Acr2p is an arsenate reductase that is related to protein phosphotyrosine phosphateses. The active site of Acr2p has the consensus phosphatese HC(X)5R motif. [3] [4]
Purified Acr2p reduces arsenate to arsenite using glutaredoxin and GSH as reductants. [2] [4]
Protein Details
Protein Function/Process
Disruption of ACR2 resulted in senstivity to arsenate but not arsenite. Purified Acr2p was shown to have arsenate reductase activity. [1] [4]
Acr2p, which is related to protein phosphotyrosine phosphatases, has arsenate reductase activity but not protein phosphotyrosine phosphatase activity. Three mutations were sufficient to change the activity from a reductase to a phosphatase. [5] [4]
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References
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- ↑ 1.0 1.1 Mukhopadhyay R and Rosen BP (1998) Saccharomyces cerevisiae ACR2 gene encodes an arsenate reductase. FEMS Microbiol Lett 168(1):127-36 SGD PMID 9812373
- ↑ 2.0 2.1 Mukhopadhyay R, et al. (2000) Purification and characterization of ACR2p, the Saccharomyces cerevisiae arsenate reductase. J Biol Chem 275(28):21149-57
SGD PMID 10801893 Cite error: Invalid
<ref>tag; name "S000054698" defined multiple times with different content - ↑ Mukhopadhyay R and Rosen BP (2001) The phosphatase C(X)5R motif is required for catalytic activity of the Saccharomyces cerevisiae Acr2p arsenate reductase. J Biol Chem 276(37):34738-42 SGD PMID 11461905
- ↑ 4.0 4.1 4.2 4.3 submitted by Barry Rosen on 2003-07-31
- ↑ Mukhopadhyay R, et al. (2003) Directed evolution of a yeast arsenate reductase into a protein-tyrosine phosphatase. J Biol Chem 278(27):24476-80 SGD PMID 12711608
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