Difference between revisions of "YPR173C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000006377 YPR173C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''VPS4 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''VPS4 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XVI: | + | |nowrap| Chr XVI:887837..886524 |
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000006377 | ||
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| − | '''Description of | + | '''Description of YPR173C:''' AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism<ref name='S000120430'>Azmi I, et al. (2006) Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1. J Cell Biol 172(5):705-17 {{SGDpaper|S000120430}} PMID 16505166</ref><ref name='S000044124'>Babst M, et al. (1998) The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J 17(11):2982-93 {{SGDpaper|S000044124}} PMID 9606181</ref><ref name='S000071351'>Babst M, et al. (2002) Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting. Dev Cell 3(2):271-82 {{SGDpaper|S000071351}} PMID 12194857</ref><ref name='S000069459'>Kumar A, et al. (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19 {{SGDpaper|S000069459}} PMID 11914276</ref><ref name='S000114798'>Lottridge JM, et al. (2006) Vta1p and Vps46p regulate the membrane association and ATPase activity of Vps4p at the yeast multivesicular body. Proc Natl Acad Sci U S A 103(16):6202-7 {{SGDpaper|S000114798}} PMID 16601096</ref><ref name='S000086181'>Wang P, et al. (2005) AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism. EMBO J 24(17):2989-99 |
| − | {{SGDpaper| | + | {{SGDpaper|S000086181}} PMID 16096648</ref> |
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==Community Commentary== | ==Community Commentary== | ||
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| + | <!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation --> | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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Latest revision as of 06:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YPR173C |
| Gene name | VPS4 |
| Aliases | CSC1, DID6, END13, GRD13, VPL4, VPT10 |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:887837..886524 |
| Primary SGDID | S000006377 |
Description of YPR173C: AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism[1][2][3][4][5][6]
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References
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- ↑ Azmi I, et al. (2006) Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1. J Cell Biol 172(5):705-17 SGD PMID 16505166
- ↑ Babst M, et al. (1998) The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J 17(11):2982-93 SGD PMID 9606181
- ↑ Babst M, et al. (2002) Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting. Dev Cell 3(2):271-82 SGD PMID 12194857
- ↑ Kumar A, et al. (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19 SGD PMID 11914276
- ↑ Lottridge JM, et al. (2006) Vta1p and Vps46p regulate the membrane association and ATPase activity of Vps4p at the yeast multivesicular body. Proc Natl Acad Sci U S A 103(16):6202-7 SGD PMID 16601096
- ↑ Wang P, et al. (2005) AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism. EMBO J 24(17):2989-99 SGD PMID 16096648
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