Difference between revisions of "YPR140W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000006344 YPR140W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''TAZ1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''TAZ1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XVI: | + | |nowrap| Chr XVI:814391..815536 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000006344 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000006344 | ||
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| − | '''Description of YPR140W:''' Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; | + | '''Description of YPR140W:''' Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome<ref name='S000075500'>Gu Z, et al. (2004) Aberrant cardiolipin metabolism in the yeast taz1 mutant: a model for Barth syndrome. Mol Microbiol 51(1):149-58 {{SGDpaper|S000075500}} PMID 14651618</ref><ref name='S000065692'>Neuwald AF (1997) Barth syndrome may be due to an acyltransferase deficiency. Curr Biol 7(8):R465-6 {{SGDpaper|S000065692}} PMID 9259571</ref><ref name='S000080116'>Testet E, et al. (2005) Ypr140wp, 'the yeast tafazzin', displays a mitochondrial lysophosphatidylcholine (lyso-PC) acyltransferase activity related to triacylglycerol and mitochondrial lipid synthesis. Biochem J 387(Pt 3):617-26 |
| − | {{SGDpaper| | + | {{SGDpaper|S000080116}} PMID 15588229</ref> |
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Latest revision as of 06:45, 23 January 2012
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| Systematic name | YPR140W |
| Gene name | TAZ1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:814391..815536 |
| Primary SGDID | S000006344 |
Description of YPR140W: Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome[1][2][3]
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References
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- ↑ Gu Z, et al. (2004) Aberrant cardiolipin metabolism in the yeast taz1 mutant: a model for Barth syndrome. Mol Microbiol 51(1):149-58 SGD PMID 14651618
- ↑ Neuwald AF (1997) Barth syndrome may be due to an acyltransferase deficiency. Curr Biol 7(8):R465-6 SGD PMID 9259571
- ↑ Testet E, et al. (2005) Ypr140wp, 'the yeast tafazzin', displays a mitochondrial lysophosphatidylcholine (lyso-PC) acyltransferase activity related to triacylglycerol and mitochondrial lipid synthesis. Biochem J 387(Pt 3):617-26 SGD PMID 15588229
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