Difference between revisions of "YPR062W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000006266 YPR062W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''FCY1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''FCY1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XVI: | + | |nowrap| Chr XVI:677165..677641 |
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| − | | | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000006266 |
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| − | '''Description of | + | '''Description of YPR062W:''' Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)<ref name='S000054250'>Erbs P, et al. (1997) Characterization of the Saccharomyces cerevisiae FCY1 gene encoding cytosine deaminase and its homologue FCA1 of Candida albicans. Curr Genet 31(1):1-6 {{SGDpaper|S000054250}} PMID 9000374</ref><ref name='S000081442'>Yao L, et al. (2005) Product release is rate-limiting in the activation of the prodrug 5-fluorocytosine by yeast cytosine deaminase. Biochemistry 44(15):5940-7 |
| − | {{SGDpaper| | + | {{SGDpaper|S000081442}} PMID 15823054</ref> |
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==Community Commentary== | ==Community Commentary== | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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==References== | ==References== | ||
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Latest revision as of 06:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YPR062W |
| Gene name | FCY1 |
| Aliases | yCD |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:677165..677641 |
| Primary SGDID | S000006266 |
Description of YPR062W: Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)[1][2]
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Contents
Community Commentary
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References
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- ↑ Erbs P, et al. (1997) Characterization of the Saccharomyces cerevisiae FCY1 gene encoding cytosine deaminase and its homologue FCA1 of Candida albicans. Curr Genet 31(1):1-6 SGD PMID 9000374
- ↑ Yao L, et al. (2005) Product release is rate-limiting in the activation of the prodrug 5-fluorocytosine by yeast cytosine deaminase. Biochemistry 44(15):5940-7 SGD PMID 15823054
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