Difference between revisions of "YPL267W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000006188 YPL267W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''ACM1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''ACM1 '' | ||
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|nowrap| Chr XVI:38169..38798 | |nowrap| Chr XVI:38169..38798 | ||
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| − | | | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000006188 |
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| − | '''Description of | + | '''Description of YPL267W:''' Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein<ref name='S000126489'>Enquist-Newman M, et al. (2008) Modulation of the Mitotic Regulatory Network by APC-Dependent Destruction of the Cdh1 Inhibitor Acm1. Mol Cell 30(4):437-46 {{SGDpaper|S000126489}} PMID 18498748</ref><ref name='S000119207'>Martinez JS, et al. (2006) Acm1 is a negative regulator of the CDH1-dependent anaphase-promoting complex/cyclosome in budding yeast. Mol Cell Biol 26(24):9162-76 {{SGDpaper|S000119207}} PMID 17030612</ref><ref name='S000126632'>Ostapenko D, et al. (2008) Pseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation. Mol Cell Biol 28(15):4653-64 {{SGDpaper|S000126632}} PMID 18519589</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 |
{{SGDpaper|S000074306}} PMID 14574415</ref> | {{SGDpaper|S000074306}} PMID 14574415</ref> | ||
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==Community Commentary== | ==Community Commentary== | ||
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| + | === Protein Details === | ||
| + | [[Category:Topic:Protein Details]] | ||
| + | ==== Protein Modification ==== | ||
| + | [[Category:Topic:Protein Details:Protein Modification]] | ||
| + | '''Modification(s)''': Phosphorylation [[Category:Modification:Phosphorylation]] | ||
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| + | Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. <ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref> <ref name = 'CAset7903-2004-01-29'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=7903 Jeff Ubersax] on 2004-01-29</ref> | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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==References== | ==References== | ||
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Latest revision as of 06:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YPL267W |
| Gene name | ACM1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:38169..38798 |
| Primary SGDID | S000006188 |
Description of YPL267W: Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein[1][2][3][4]
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Community Commentary
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [5]
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References
See Help:References on how to add references
- ↑ Enquist-Newman M, et al. (2008) Modulation of the Mitotic Regulatory Network by APC-Dependent Destruction of the Cdh1 Inhibitor Acm1. Mol Cell 30(4):437-46 SGD PMID 18498748
- ↑ Martinez JS, et al. (2006) Acm1 is a negative regulator of the CDH1-dependent anaphase-promoting complex/cyclosome in budding yeast. Mol Cell Biol 26(24):9162-76 SGD PMID 17030612
- ↑ Ostapenko D, et al. (2008) Pseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation. Mol Cell Biol 28(15):4653-64 SGD PMID 18519589
- ↑ 4.0 4.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
SGD PMID 14574415 Cite error: Invalid
<ref>tag; name "S000074306" defined multiple times with different content - ↑ submitted by Jeff Ubersax on 2004-01-29
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
