Difference between revisions of "YPL194W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000006115 YPL194W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''DDC1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''DDC1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XVI: | + | |nowrap| Chr XVI:179277..181115 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000006115 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000006115 | ||
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| − | '''Description of YPL194W:''' DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate<ref name='S000069127'>Hong EJ and Roeder GS (2002) A role for Ddc1 in signaling meiotic double-strand breaks at the pachytene checkpoint. Genes Dev 16(3):363-76 {{SGDpaper|S000069127}} PMID 11825877</ref><ref name='S000069695'>Wang H and Elledge SJ (2002) Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics 160(4):1295-304 {{SGDpaper|S000069695}} PMID 11973288 | + | '''Description of YPL194W:''' DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate<ref name='S000073404'>Giannattasio M, et al. (2003) Correlation between checkpoint activation and in vivo assembly of the yeast checkpoint complex Rad17-Mec3-Ddc1. J Biol Chem 278(25):22303-8 {{SGDpaper|S000073404}} PMID 12672803</ref><ref name='S000069127'>Hong EJ and Roeder GS (2002) A role for Ddc1 in signaling meiotic double-strand breaks at the pachytene checkpoint. Genes Dev 16(3):363-76 {{SGDpaper|S000069127}} PMID 11825877</ref><ref name='S000069695'>Wang H and Elledge SJ (2002) Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics 160(4):1295-304 |
| − | + | {{SGDpaper|S000069695}} PMID 11973288</ref> | |
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Latest revision as of 06:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YPL194W |
| Gene name | DDC1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:179277..181115 |
| Primary SGDID | S000006115 |
Description of YPL194W: DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate[1][2][3]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [5]
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References
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- ↑ Giannattasio M, et al. (2003) Correlation between checkpoint activation and in vivo assembly of the yeast checkpoint complex Rad17-Mec3-Ddc1. J Biol Chem 278(25):22303-8 SGD PMID 12672803
- ↑ Hong EJ and Roeder GS (2002) A role for Ddc1 in signaling meiotic double-strand breaks at the pachytene checkpoint. Genes Dev 16(3):363-76 SGD PMID 11825877
- ↑ Wang H and Elledge SJ (2002) Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics 160(4):1295-304 SGD PMID 11973288
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-29
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