Difference between revisions of "YPL094C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YPL094C YPL094C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000006015 YPL094C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SEC62 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SEC62 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr XVI:370660..369836
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|nowrap| Chr XVI:370663..369839
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000006015
 
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'''Description of {{PAGENAME}}:''' Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER<ref name='S000072462'>Willer M, et al. (2003) Identification of novel protein-protein interactions at the cytosolic surface of the Sec63 complex in the yeast ER membrane. Yeast 20(2):133-48 {{SGDpaper|S000072462}} PMID 12518317</ref><ref name='S000060140'>Young BP, et al. (2001) Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo. EMBO J 20(1-2):262-71 {{SGDpaper|S000060140}} PMID 11226176</ref><ref name='S000050000'>Deshaies RJ and Schekman R (1989) SEC62 encodes a putative membrane protein required for protein translocation into the yeast endoplasmic reticulum. J Cell Biol 109(6 Pt 1):2653-64
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'''Description of YPL094C:''' Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER<ref name='S000050000'>Deshaies RJ and Schekman R (1989) SEC62 encodes a putative membrane protein required for protein translocation into the yeast endoplasmic reticulum. J Cell Biol 109(6 Pt 1):2653-64 {{SGDpaper|S000050000}} PMID 2687286</ref><ref name='S000072462'>Willer M, et al. (2003) Identification of novel protein-protein interactions at the cytosolic surface of the Sec63 complex in the yeast ER membrane. Yeast 20(2):133-48 {{SGDpaper|S000072462}} PMID 12518317</ref><ref name='S000060140'>Young BP, et al. (2001) Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo. EMBO J 20(1-2):262-71
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{{SGDpaper|S000050000}} PMID 2687286</ref>
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{{SGDpaper|S000060140}} PMID 11226176</ref>
 
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==Community Commentary==
 
==Community Commentary==
 
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=== DNA and RNA Details ===
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[[Category:Topic:DNA and RNA Details]]
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==== Transcription Start ====
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[[Category:Topic:DNA and RNA Details:Transcription Start]]
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'''Transcription start(s)''': 369837,370712
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Transcription starts at co-ordinate 370694 or 370695 <ref name='S000072462'>Willer M, et al. (2003) Identification of novel protein-protein interactions at the cytosolic surface of the Sec63 complex in the yeast ER membrane. Yeast 20(2):133-48 {{SGDpaper|S000072462}} PMID 12518317</ref> <ref name = 'CAset7415-2003-02-05'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=7415 Colin Stirling] on 2003-02-05</ref>
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=== Interactions ===
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[[Category:Topic:Interactions]]
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==== Two Hybrid ====
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[[Category:Topic:Interactions:Two Hybrid]]
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Two Hybrid interaction with SEC63 [[Category:Two Hybrid Interactions with SEC63]]<br>
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Amino terminal domain of Sec62p (residues 1-149) interacts with c-terminal 39 residues of Sec63p <ref name='S000072462'>Willer M, et al. (2003) Identification of novel protein-protein interactions at the cytosolic surface of the Sec63 complex in the yeast ER membrane. Yeast 20(2):133-48 {{SGDpaper|S000072462}} PMID 12518317</ref> <ref name = 'CAset7415-2003-02-05'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=7415 Colin Stirling] on 2003-02-05</ref>
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=== Protein Details ===
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[[Category:Topic:Protein Details]]
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==== Mature Length (direct evidence) ====
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[[Category:Topic:Protein Details:Mature Length (direct evidence)]]
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'''Protein length''': 274 aa
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The authentic translation start occurs at the AUG codon located at co-ordinate 370658 and not at the cryptic AUG located 27bp upstream (370685). The primary translation product is thus 274 amino acid residues in length and not 283 as previously supposed. <ref name='S000072462'>Willer M, et al. (2003) Identification of novel protein-protein interactions at the cytosolic surface of the Sec63 complex in the yeast ER membrane. Yeast 20(2):133-48 {{SGDpaper|S000072462}} PMID 12518317</ref> <ref name = 'CAset7415-2003-02-05'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=7415 Colin Stirling] on 2003-02-05</ref>
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 06:45, 23 January 2012

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Systematic name YPL094C
Gene name SEC62
Aliases LPG14
Feature type ORF, Verified
Coordinates Chr XVI:370663..369839
Primary SGDID S000006015


Description of YPL094C: Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER[1][2][3]




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Community Commentary

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DNA and RNA Details

Transcription Start

Transcription start(s): 369837,370712 Transcription starts at co-ordinate 370694 or 370695 [2] [4]

Interactions

Two Hybrid

Two Hybrid interaction with SEC63
Amino terminal domain of Sec62p (residues 1-149) interacts with c-terminal 39 residues of Sec63p [2] [4]

Protein Details

Mature Length (direct evidence)

Protein length: 274 aa The authentic translation start occurs at the AUG codon located at co-ordinate 370658 and not at the cryptic AUG located 27bp upstream (370685). The primary translation product is thus 274 amino acid residues in length and not 283 as previously supposed. [2] [4]




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References

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  1. ↑ Deshaies RJ and Schekman R (1989) SEC62 encodes a putative membrane protein required for protein translocation into the yeast endoplasmic reticulum. J Cell Biol 109(6 Pt 1):2653-64 SGD PMID 2687286
  2. ↑ 2.0 2.1 2.2 2.3 Willer M, et al. (2003) Identification of novel protein-protein interactions at the cytosolic surface of the Sec63 complex in the yeast ER membrane. Yeast 20(2):133-48 SGD PMID 12518317
  3. ↑ Young BP, et al. (2001) Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo. EMBO J 20(1-2):262-71 SGD PMID 11226176
  4. ↑ 4.0 4.1 4.2 submitted by Colin Stirling on 2003-02-05

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