Difference between revisions of "YPL094C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000006015 YPL094C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SEC62 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SEC62 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XVI: | + | |nowrap| Chr XVI:370663..369839 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000006015 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000006015 | ||
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| − | '''Description of YPL094C:''' Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER<ref name='S000050000'>Deshaies RJ and Schekman R (1989) SEC62 encodes a putative membrane protein required for protein translocation into the yeast endoplasmic reticulum. J Cell Biol 109(6 Pt 1):2653-64 {{SGDpaper|S000050000}} PMID 2687286</ref><ref name=' | + | '''Description of YPL094C:''' Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER<ref name='S000050000'>Deshaies RJ and Schekman R (1989) SEC62 encodes a putative membrane protein required for protein translocation into the yeast endoplasmic reticulum. J Cell Biol 109(6 Pt 1):2653-64 {{SGDpaper|S000050000}} PMID 2687286</ref><ref name='S000072462'>Willer M, et al. (2003) Identification of novel protein-protein interactions at the cytosolic surface of the Sec63 complex in the yeast ER membrane. Yeast 20(2):133-48 {{SGDpaper|S000072462}} PMID 12518317</ref><ref name='S000060140'>Young BP, et al. (2001) Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo. EMBO J 20(1-2):262-71 |
| − | {{SGDpaper| | + | {{SGDpaper|S000060140}} PMID 11226176</ref> |
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Latest revision as of 06:45, 23 January 2012
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| Systematic name | YPL094C |
| Gene name | SEC62 |
| Aliases | LPG14 |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:370663..369839 |
| Primary SGDID | S000006015 |
Description of YPL094C: Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER[1][2][3]
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Contents
Community Commentary
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DNA and RNA Details
Transcription Start
Transcription start(s): 369837,370712 Transcription starts at co-ordinate 370694 or 370695 [2] [4]
Interactions
Two Hybrid
Two Hybrid interaction with SEC63
Amino terminal domain of Sec62p (residues 1-149) interacts with c-terminal 39 residues of Sec63p [2] [4]
Protein Details
Mature Length (direct evidence)
Protein length: 274 aa The authentic translation start occurs at the AUG codon located at co-ordinate 370658 and not at the cryptic AUG located 27bp upstream (370685). The primary translation product is thus 274 amino acid residues in length and not 283 as previously supposed. [2] [4]
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References
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- ↑ Deshaies RJ and Schekman R (1989) SEC62 encodes a putative membrane protein required for protein translocation into the yeast endoplasmic reticulum. J Cell Biol 109(6 Pt 1):2653-64 SGD PMID 2687286
- ↑ 2.0 2.1 2.2 2.3 Willer M, et al. (2003) Identification of novel protein-protein interactions at the cytosolic surface of the Sec63 complex in the yeast ER membrane. Yeast 20(2):133-48 SGD PMID 12518317
- ↑ Young BP, et al. (2001) Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo. EMBO J 20(1-2):262-71 SGD PMID 11226176
- ↑ 4.0 4.1 4.2 submitted by Colin Stirling on 2003-02-05
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