Difference between revisions of "YOR153W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YOR153W YOR153W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005679 YOR153W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''PDR5 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''PDR5 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr XV:619841..624376
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|nowrap| Chr XV:619840..624375
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000005679
 
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'''Description of {{PAGENAME}}:''' Short-lived membrane ABC (ATP-binding cassette) transporter, actively exports various drugs, expression regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth<ref name='S000075843'>Mamnun YM, et al. (2004) Expression regulation of the yeast PDR5 ATP-binding cassette (ABC) transporter suggests a role in cellular detoxification during the exponential growth phase. FEBS Lett 559(1-3):111-7 {{SGDpaper|S000075843}} PMID 14960317</ref><ref name='S000069994'>Emter R, et al. (2002) ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms. FEBS Lett 521(1-3):57-61 {{SGDpaper|S000069994}} PMID 12067726</ref><ref name='S000052729'>Egner R and Kuchler K (1996) The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole. FEBS Lett 378(2):177-81 {{SGDpaper|S000052729}} PMID 8549828</ref><ref name='S000043769'>Egner R, et al. (1995) Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae. Mol Cell Biol 15(11):5879-87 {{SGDpaper|S000043769}} PMID 7565740</ref><ref name='S000042972'>Bissinger PH and Kuchler K (1994) Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance. J Biol Chem 269(6):4180-6 {{SGDpaper|S000042972}} PMID 8307980</ref><ref name='S000042556'>Miyahara K, et al. (1996) The involvement of the Saccharomyces cerevisiae multidrug resistance transporters Pdr5p and Snq2p in cation resistance. FEBS Lett 399(3):317-20 {{SGDpaper|S000042556}} PMID 8985171</ref><ref name='S000042040'>Balzi E, et al. (1994) PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1. J Biol Chem 269(3):2206-14 {{SGDpaper|S000042040}} PMID 8294477</ref><ref name='S000040660'>Mahe Y, et al. (1996) The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo. J Biol Chem 271(41):25167-72
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'''Description of YOR153W:''' Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth<ref name='S000042040'>Balzi E, et al. (1994) PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1. J Biol Chem 269(3):2206-14 {{SGDpaper|S000042040}} PMID 8294477</ref><ref name='S000042972'>Bissinger PH and Kuchler K (1994) Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance. J Biol Chem 269(6):4180-6 {{SGDpaper|S000042972}} PMID 8307980</ref><ref name='S000052729'>Egner R and Kuchler K (1996) The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole. FEBS Lett 378(2):177-81 {{SGDpaper|S000052729}} PMID 8549828</ref><ref name='S000043769'>Egner R, et al. (1995) Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae. Mol Cell Biol 15(11):5879-87 {{SGDpaper|S000043769}} PMID 7565740</ref><ref name='S000069994'>Emter R, et al. (2002) ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms. FEBS Lett 521(1-3):57-61 {{SGDpaper|S000069994}} PMID 12067726</ref><ref name='S000040660'>Mahe Y, et al. (1996) The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo. J Biol Chem 271(41):25167-72 {{SGDpaper|S000040660}} PMID 8810273</ref><ref name='S000075843'>Mamnun YM, et al. (2004) Expression regulation of the yeast PDR5 ATP-binding cassette (ABC) transporter suggests a role in cellular detoxification during the exponential growth phase. FEBS Lett 559(1-3):111-7 {{SGDpaper|S000075843}} PMID 14960317</ref><ref name='S000042556'>Miyahara K, et al. (1996) The involvement of the Saccharomyces cerevisiae multidrug resistance transporters Pdr5p and Snq2p in cation resistance. FEBS Lett 399(3):317-20 {{SGDpaper|S000042556}} PMID 8985171</ref><ref name='S000060194'>Rogers B, et al. (2001) The pleitropic drug ABC transporters from Saccharomyces cerevisiae. J Mol Microbiol Biotechnol 3(2):207-14
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  {{SGDpaper|S000060194}} PMID 11321575</ref>
 
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==Community Commentary==
 
==Community Commentary==
 
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 06:45, 23 January 2012

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Systematic name YOR153W
Gene name PDR5
Aliases LEM1, STS1, YDR1
Feature type ORF, Verified
Coordinates Chr XV:619840..624375
Primary SGDID S000005679


Description of YOR153W: Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth[1][2][3][4][5][6][7][8][9]




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References

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  1. ↑ Balzi E, et al. (1994) PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1. J Biol Chem 269(3):2206-14 SGD PMID 8294477
  2. ↑ Bissinger PH and Kuchler K (1994) Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance. J Biol Chem 269(6):4180-6 SGD PMID 8307980
  3. ↑ Egner R and Kuchler K (1996) The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole. FEBS Lett 378(2):177-81 SGD PMID 8549828
  4. ↑ Egner R, et al. (1995) Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae. Mol Cell Biol 15(11):5879-87 SGD PMID 7565740
  5. ↑ Emter R, et al. (2002) ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms. FEBS Lett 521(1-3):57-61 SGD PMID 12067726
  6. ↑ Mahe Y, et al. (1996) The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo. J Biol Chem 271(41):25167-72 SGD PMID 8810273
  7. ↑ Mamnun YM, et al. (2004) Expression regulation of the yeast PDR5 ATP-binding cassette (ABC) transporter suggests a role in cellular detoxification during the exponential growth phase. FEBS Lett 559(1-3):111-7 SGD PMID 14960317
  8. ↑ Miyahara K, et al. (1996) The involvement of the Saccharomyces cerevisiae multidrug resistance transporters Pdr5p and Snq2p in cation resistance. FEBS Lett 399(3):317-20 SGD PMID 8985171
  9. ↑ Rogers B, et al. (2001) The pleitropic drug ABC transporters from Saccharomyces cerevisiae. J Mol Microbiol Biotechnol 3(2):207-14 SGD PMID 11321575

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