Difference between revisions of "YOL100W"
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− | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005460 YOL100W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PKH2 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PKH2 '' | ||
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− | '''Description of YOL100W:''' Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p<ref name='S000053842'>Casamayor A, et al. (1999) Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol 9(4):186-97 {{SGDpaper|S000053842}} PMID 10074427</ref><ref name='S000069021'>Friant S, et al. (2001) Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast. EMBO J 20(23):6783-92 {{SGDpaper|S000069021}} PMID 11726514</ref><ref name='S000048917'>Inagaki M, et al. (1999) PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast. Mol Cell Biol 19(12):8344-52 {{SGDpaper|S000048917}} PMID 10567559</ref><ref name='S000071423'>Roelants FM, et al. (2002) Pkh1 and | + | '''Description of YOL100W:''' Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p<ref name='S000053842'>Casamayor A, et al. (1999) Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol 9(4):186-97 {{SGDpaper|S000053842}} PMID 10074427</ref><ref name='S000069021'>Friant S, et al. (2001) Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast. EMBO J 20(23):6783-92 {{SGDpaper|S000069021}} PMID 11726514</ref><ref name='S000048917'>Inagaki M, et al. (1999) PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast. Mol Cell Biol 19(12):8344-52 {{SGDpaper|S000048917}} PMID 10567559</ref><ref name='S000071423'>Roelants FM, et al. (2002) Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity. Mol Biol Cell 13(9):3005-28 |
{{SGDpaper|S000071423}} PMID 12221112</ref> | {{SGDpaper|S000071423}} PMID 12221112</ref> | ||
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Latest revision as of 07:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
Systematic name | YOL100W |
Gene name | PKH2 |
Aliases | |
Feature type | ORF, Verified |
Coordinates | Chr XV:129237..132482 |
Primary SGDID | S000005460 |
Description of YOL100W: Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p[1][2][3][4]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [5] [6]
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References
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- ↑ Casamayor A, et al. (1999) Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol 9(4):186-97 SGD PMID 10074427
- ↑ Friant S, et al. (2001) Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast. EMBO J 20(23):6783-92 SGD PMID 11726514
- ↑ Inagaki M, et al. (1999) PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast. Mol Cell Biol 19(12):8344-52 SGD PMID 10567559
- ↑ Roelants FM, et al. (2002) Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity. Mol Biol Cell 13(9):3005-28 SGD PMID 12221112
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-29
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