Difference between revisions of "YOL034W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YOL034W YOL034W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005394 YOL034W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SMC5 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SMC5 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr XV:259924..263205
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|nowrap| Chr XV:259923..263204
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000005394
 
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'''Description of {{PAGENAME}}:''' Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair<ref name='S000080949'>Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 {{SGDpaper|S000080949}} PMID 15738391</ref><ref name='S000075870'>Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst) 3(4):429-39 {{SGDpaper|S000075870}} PMID 15010319</ref><ref name='S000069988'>Fujioka Y, et al. (2002) Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. J Biol Chem 277(24):21585-91
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'''Description of YOL034W:''' Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair<ref name='S000142482'>Bermudez-Lopez M, et al. (2010) The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages. Nucleic Acids Res 38(19):6502-12 {{SGDpaper|S000142482}} PMID 20571088</ref><ref name='S000069988'>Fujioka Y, et al. (2002) Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. J Biol Chem 277(24):21585-91 {{SGDpaper|S000069988}} PMID 11927594</ref><ref name='S000075870'>Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst) 3(4):429-39 {{SGDpaper|S000075870}} PMID 15010319</ref><ref name='S000146610'>Roy MA, et al. (2011) Dynamic and selective DNA-binding activity of Smc5, a core component of the Smc5-Smc6 complex. Cell Cycle 10(4):690-700 {{SGDpaper|S000146610}} PMID 21293191</ref><ref name='S000080949'>Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82
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  {{SGDpaper|S000069988}} PMID 11927594</ref>
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  {{SGDpaper|S000080949}} PMID 15738391</ref>
 
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Smc5 is one of the two SMC proteins that forms the core of the Smc5-Smc6 complex. The Smc5-Smc6 complex is, together with cohesin and condensin, one of the three essential eukaryotic SMC complexes. The complex has six non-Smc subunits, named Nse1, Nse2, Nse3, Nse4, Nse5 and Nse6. The Smc5-Smc6 complex has been shown to have a role in DNA repair, as well as an essential function. Smc5-Smc6 participates in an undefined step of homologous recombination <ref>Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst). 3(4):429-39</ref> and it is recruited to DNA double strand breaks to promote sister chromatid recombination <ref>de Piccoli G, et al. (2006) Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. Nat Cell Biol. 8(9):1032-4 </ref>. The essential function of the Smc5-Smc6 complex is most probably related to chromosome segregation. The Smc5-Smc6 complex binds to the ribosomal DNA array (rDNA) <ref>Torres-Rosell J, et al. (2005) SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions. Nat Cell Biol. 2005 7(4):412-9 </ref> and <i>smc5-smc6</i> thermosensitive mutants fail to segregate the rDNA when grown at the restrictive temperature <ref>Torres-Rosell J, et al. (2005) SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions. Nat Cell Biol. 2005 7(4):412-9 </ref> <ref>Cost GJ, Cozzarelli NR (2006) Smc5p promotes faithful chromosome transmission and DNA repair in Saccharomyces cerevisiae. Genetics 172(4):2185-200.</ref>
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==References==
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==References==
 
==References==

Latest revision as of 06:45, 23 January 2012

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Systematic name YOL034W
Gene name SMC5
Aliases
Feature type ORF, Verified
Coordinates Chr XV:259923..263204
Primary SGDID S000005394


Description of YOL034W: Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair[1][2][3][4][5]




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Community Commentary

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Smc5 is one of the two SMC proteins that forms the core of the Smc5-Smc6 complex. The Smc5-Smc6 complex is, together with cohesin and condensin, one of the three essential eukaryotic SMC complexes. The complex has six non-Smc subunits, named Nse1, Nse2, Nse3, Nse4, Nse5 and Nse6. The Smc5-Smc6 complex has been shown to have a role in DNA repair, as well as an essential function. Smc5-Smc6 participates in an undefined step of homologous recombination [6] and it is recruited to DNA double strand breaks to promote sister chromatid recombination [7]. The essential function of the Smc5-Smc6 complex is most probably related to chromosome segregation. The Smc5-Smc6 complex binds to the ribosomal DNA array (rDNA) [8] and smc5-smc6 thermosensitive mutants fail to segregate the rDNA when grown at the restrictive temperature [9] [10]



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References

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  1. ↑ Bermudez-Lopez M, et al. (2010) The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages. Nucleic Acids Res 38(19):6502-12 SGD PMID 20571088
  2. ↑ Fujioka Y, et al. (2002) Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. J Biol Chem 277(24):21585-91 SGD PMID 11927594
  3. ↑ Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst) 3(4):429-39 SGD PMID 15010319
  4. ↑ Roy MA, et al. (2011) Dynamic and selective DNA-binding activity of Smc5, a core component of the Smc5-Smc6 complex. Cell Cycle 10(4):690-700 SGD PMID 21293191
  5. ↑ Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 SGD PMID 15738391
  6. ↑ Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst). 3(4):429-39
  7. ↑ de Piccoli G, et al. (2006) Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. Nat Cell Biol. 8(9):1032-4
  8. ↑ Torres-Rosell J, et al. (2005) SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions. Nat Cell Biol. 2005 7(4):412-9
  9. ↑ Torres-Rosell J, et al. (2005) SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions. Nat Cell Biol. 2005 7(4):412-9
  10. ↑ Cost GJ, Cozzarelli NR (2006) Smc5p promotes faithful chromosome transmission and DNA repair in Saccharomyces cerevisiae. Genetics 172(4):2185-200.

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References

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See Help:Categories on how to add the wiki page for this gene to a Category </protect>

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