Difference between revisions of "YOL034W"
SGDwikiBot (talk | contribs) (Automated import of articles) |
SGDwikiBot (talk | contribs) (Automated import of articles) |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 4: | Line 4: | ||
{|{{Prettytable}} align = 'right' width = '200px' | {|{{Prettytable}} align = 'right' width = '200px' | ||
|- | |- | ||
| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005394 YOL034W] |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SMC5 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SMC5 '' | ||
| Line 13: | Line 13: | ||
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XV: | + | |nowrap| Chr XV:259923..263204 |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005394 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005394 | ||
|} | |} | ||
<br> | <br> | ||
| − | '''Description of YOL034W:''' | + | '''Description of YOL034W:''' Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair<ref name='S000142482'>Bermudez-Lopez M, et al. (2010) The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages. Nucleic Acids Res 38(19):6502-12 {{SGDpaper|S000142482}} PMID 20571088</ref><ref name='S000069988'>Fujioka Y, et al. (2002) Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. J Biol Chem 277(24):21585-91 {{SGDpaper|S000069988}} PMID 11927594</ref><ref name='S000075870'>Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst) 3(4):429-39 {{SGDpaper|S000075870}} PMID 15010319</ref><ref name='S000146610'>Roy MA, et al. (2011) Dynamic and selective DNA-binding activity of Smc5, a core component of the Smc5-Smc6 complex. Cell Cycle 10(4):690-700 {{SGDpaper|S000146610}} PMID 21293191</ref><ref name='S000080949'>Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 |
{{SGDpaper|S000080949}} PMID 15738391</ref> | {{SGDpaper|S000080949}} PMID 15738391</ref> | ||
<br> | <br> | ||
Latest revision as of 06:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YOL034W |
| Gene name | SMC5 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:259923..263204 |
| Primary SGDID | S000005394 |
Description of YOL034W: Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair[1][2][3][4][5]
</protect>
Community Commentary
About Community Commentary. Please share your knowledge!
Smc5 is one of the two SMC proteins that forms the core of the Smc5-Smc6 complex. The Smc5-Smc6 complex is, together with cohesin and condensin, one of the three essential eukaryotic SMC complexes. The complex has six non-Smc subunits, named Nse1, Nse2, Nse3, Nse4, Nse5 and Nse6. The Smc5-Smc6 complex has been shown to have a role in DNA repair, as well as an essential function. Smc5-Smc6 participates in an undefined step of homologous recombination [6] and it is recruited to DNA double strand breaks to promote sister chromatid recombination [7]. The essential function of the Smc5-Smc6 complex is most probably related to chromosome segregation. The Smc5-Smc6 complex binds to the ribosomal DNA array (rDNA) [8] and smc5-smc6 thermosensitive mutants fail to segregate the rDNA when grown at the restrictive temperature [9] [10]
<protect>
References
See Help:References on how to add references
- ↑ Bermudez-Lopez M, et al. (2010) The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages. Nucleic Acids Res 38(19):6502-12 SGD PMID 20571088
- ↑ Fujioka Y, et al. (2002) Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. J Biol Chem 277(24):21585-91 SGD PMID 11927594
- ↑ Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst) 3(4):429-39 SGD PMID 15010319
- ↑ Roy MA, et al. (2011) Dynamic and selective DNA-binding activity of Smc5, a core component of the Smc5-Smc6 complex. Cell Cycle 10(4):690-700 SGD PMID 21293191
- ↑ Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 SGD PMID 15738391
- ↑ Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst). 3(4):429-39
- ↑ de Piccoli G, et al. (2006) Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. Nat Cell Biol. 8(9):1032-4
- ↑ Torres-Rosell J, et al. (2005) SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions. Nat Cell Biol. 2005 7(4):412-9
- ↑ Torres-Rosell J, et al. (2005) SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions. Nat Cell Biol. 2005 7(4):412-9
- ↑ Cost GJ, Cozzarelli NR (2006) Smc5p promotes faithful chromosome transmission and DNA repair in Saccharomyces cerevisiae. Genetics 172(4):2185-200.
See Help:Categories on how to add the wiki page for this gene to a Category </protect> <protect>
References
See Help:References on how to add references
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
