Difference between revisions of "YOL010W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005370 YOL010W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005370 YOL010W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''RCL1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''RCL1 ''
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'''Description of YOL010W:''' Subunit of U3-containing 90S preribosome processome complex involved in 18S rRNA biogenesis and small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no activity detected<ref name='S000039255'>Billy E, et al. (2000) Rcl1p, the yeast protein similar to the RNA 3'-phosphate cyclase, associates with U3 snoRNP and is required for 18S rRNA biogenesis. EMBO J 19(9):2115-26 {{SGDpaper|S000039255}} PMID 10790377</ref><ref name='S000086600'>Grandi P, et al. (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15 {{SGDpaper|S000086600}} PMID 12150911</ref><ref name='S000113784'>Karbstein K, et al. (2005) An essential GTPase promotes assembly of preribosomal RNA processing complexes. Mol Cell 20(4):633-43
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'''Description of YOL010W:''' Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected<ref name='S000039255'>Billy E, et al. (2000) Rcl1p, the yeast protein similar to the RNA 3'-phosphate cyclase, associates with U3 snoRNP and is required for 18S rRNA biogenesis. EMBO J 19(9):2115-26 {{SGDpaper|S000039255}} PMID 10790377</ref><ref name='S000086600'>Grandi P, et al. (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15 {{SGDpaper|S000086600}} PMID 12150911</ref><ref name='S000146399'>Horn DM, et al. (2011) RCL1, a novel nuclease for 18S rRNA production. J Biol Chem () {{SGDpaper|S000146399}} PMID 21849504</ref><ref name='S000113784'>Karbstein K, et al. (2005) An essential GTPase promotes assembly of preribosomal RNA processing complexes. Mol Cell 20(4):633-43
 
  {{SGDpaper|S000113784}} PMID 16307926</ref>
 
  {{SGDpaper|S000113784}} PMID 16307926</ref>
 
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Latest revision as of 06:45, 23 January 2012

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Systematic name YOL010W
Gene name RCL1
Aliases
Feature type ORF, Verified
Coordinates Chr XV:307938..309041
Primary SGDID S000005370


Description of YOL010W: Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected[1][2][3][4]




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References

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  1. Billy E, et al. (2000) Rcl1p, the yeast protein similar to the RNA 3'-phosphate cyclase, associates with U3 snoRNP and is required for 18S rRNA biogenesis. EMBO J 19(9):2115-26 SGD PMID 10790377
  2. Grandi P, et al. (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15 SGD PMID 12150911
  3. Horn DM, et al. (2011) RCL1, a novel nuclease for 18S rRNA production. J Biol Chem () SGD PMID 21849504
  4. Karbstein K, et al. (2005) An essential GTPase promotes assembly of preribosomal RNA processing complexes. Mol Cell 20(4):633-43 SGD PMID 16307926

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