Difference between revisions of "YNL298W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005242 YNL298W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''CLA4 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''CLA4 '' | ||
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|nowrap| Chr XIV:68915..71443 | |nowrap| Chr XIV:68915..71443 | ||
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| − | | | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005242 |
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| − | '''Description of | + | '''Description of YNL298W:''' Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p<ref name='S000129348'>Bartholomew CR and Hardy CF (2009) p21-activated kinases Cla4 and Ste20 regulate vacuole inheritance in Saccharomyces cerevisiae. Eukaryot Cell 8(4):560-72 {{SGDpaper|S000129348}} PMID 19218422</ref><ref name='S000055422'>Benton BK, et al. (1997) Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis. Mol Cell Biol 17(9):5067-76 {{SGDpaper|S000055422}} PMID 9271384</ref><ref name='S000074263'>Caviston JP, et al. (2003) The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast. Mol Biol Cell 14(10):4051-66 {{SGDpaper|S000074263}} PMID 14517318</ref><ref name='S000057413'>Cvrckova F, et al. (1995) Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev 9(15):1817-30 {{SGDpaper|S000057413}} PMID 7649470</ref><ref name='S000131819'>Lin M, et al. (2009) The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway. Mol Biol Cell 20(22):4826-37 {{SGDpaper|S000131819}} PMID 19793923</ref><ref name='S000077127'>Versele M and Thorner J (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol 164(5):701-15 |
| − | {{SGDpaper| | + | {{SGDpaper|S000077127}} PMID 14993234</ref> |
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==Community Commentary== | ==Community Commentary== | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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==References== | ==References== | ||
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Latest revision as of 07:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YNL298W |
| Gene name | CLA4 |
| Aliases | ERC10 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:68915..71443 |
| Primary SGDID | S000005242 |
Description of YNL298W: Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p[1][2][3][4][5][6]
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Contents
Community Commentary
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References
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- ↑ Bartholomew CR and Hardy CF (2009) p21-activated kinases Cla4 and Ste20 regulate vacuole inheritance in Saccharomyces cerevisiae. Eukaryot Cell 8(4):560-72 SGD PMID 19218422
- ↑ Benton BK, et al. (1997) Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis. Mol Cell Biol 17(9):5067-76 SGD PMID 9271384
- ↑ Caviston JP, et al. (2003) The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast. Mol Biol Cell 14(10):4051-66 SGD PMID 14517318
- ↑ Cvrckova F, et al. (1995) Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev 9(15):1817-30 SGD PMID 7649470
- ↑ Lin M, et al. (2009) The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway. Mol Biol Cell 20(22):4826-37 SGD PMID 19793923
- ↑ Versele M and Thorner J (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol 164(5):701-15 SGD PMID 14993234
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