Difference between revisions of "YNL161W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005105 YNL161W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''CBK1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''CBK1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XIV: | + | |nowrap| Chr XIV:332597..334867 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005105 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005105 | ||
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| − | '''Description of YNL161W:''' Serine/threonine protein kinase | + | '''Description of YNL161W:''' Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization<ref name='S000060221'>Bidlingmaier S, et al. (2001) The Cbk1p pathway is important for polarized cell growth and cell separation in Saccharomyces cerevisiae. Mol Cell Biol 21(7):2449-62 {{SGDpaper|S000060221}} PMID 11259593</ref><ref name='S000141708'>Brace J, et al. (2011) Mitotic Exit Control of the Saccharomyces cerevisiae Ndr/LATS Kinase Cbk1 Regulates Daughter Cell Separation after Cytokinesis. Mol Cell Biol 31(4):721-735 {{SGDpaper|S000141708}} PMID 21135117</ref><ref name='S000068760'>Colman-Lerner A, et al. (2001) Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates. Cell 107(6):739-50 {{SGDpaper|S000068760}} PMID 11747810</ref><ref name='S000119966'>Jansen JM, et al. (2006) Phosphoregulation of Cbk1 is critical for RAM network control of transcription and morphogenesis. J Cell Biol 175(5):755-66 {{SGDpaper|S000119966}} PMID 17145962</ref><ref name='S000132503'>Jansen JM, et al. (2009) Cbk1 regulation of the RNA-binding protein Ssd1 integrates cell fate with translational control. Curr Biol 19(24):2114-20 {{SGDpaper|S000132503}} PMID 19962308</ref><ref name='S000144483'>Kurischko C, et al. (2011) The yeast Cbk1 kinase regulates mRNA localization via the mRNA-binding protein Ssd1. J Cell Biol 192(4):583-98 {{SGDpaper|S000144483}} PMID 21339329</ref><ref name='S000134510'>Mazanka E and Weiss EL (2010) Sequential Counteracting Kinases Restrict an Asymmetric Gene Expression Program to early G1. Mol Biol Cell 21(16):2809-20 {{SGDpaper|S000134510}} PMID 20573982</ref><ref name='S000127452'>Mazanka E, et al. (2008) The NDR/LATS family kinase Cbk1 directly controls transcriptional asymmetry. PLoS Biol 6(8):e203 {{SGDpaper|S000127452}} PMID 18715118</ref><ref name='S000074101'>Nelson B, et al. (2003) RAM: a conserved signaling network that regulates Ace2p transcriptional activity and polarized morphogenesis. Mol Biol Cell 14(9):3782-803 {{SGDpaper|S000074101}} PMID 12972564</ref><ref name='S000132464'>Panozzo C, et al. (2010) Mutations in the C-terminus of the conserved NDR kinase, Cbk1p of Saccharomyces cerevisiae, make the protein independent of upstream activators. Mol Genet Genomics 283(2):111-22 {{SGDpaper|S000132464}} PMID 19967545</ref><ref name='S000059135'>Racki WJ, et al. (2000) Cbk1p, a protein similar to the human myotonic dystrophy kinase, is essential for normal morphogenesis in Saccharomyces cerevisiae. EMBO J 19(17):4524-32 {{SGDpaper|S000059135}} PMID 10970846</ref><ref name='S000070382'>Weiss EL, et al. (2002) The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor. J Cell Biol 158(5):885-900 |
| − | {{SGDpaper| | + | {{SGDpaper|S000070382}} PMID 12196508</ref> |
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Latest revision as of 06:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YNL161W |
| Gene name | CBK1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:332597..334867 |
| Primary SGDID | S000005105 |
Description of YNL161W: Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization[1][2][3][4][5][6][7][8][9][10][11][12]
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References
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- ↑ Bidlingmaier S, et al. (2001) The Cbk1p pathway is important for polarized cell growth and cell separation in Saccharomyces cerevisiae. Mol Cell Biol 21(7):2449-62 SGD PMID 11259593
- ↑ Brace J, et al. (2011) Mitotic Exit Control of the Saccharomyces cerevisiae Ndr/LATS Kinase Cbk1 Regulates Daughter Cell Separation after Cytokinesis. Mol Cell Biol 31(4):721-735 SGD PMID 21135117
- ↑ Colman-Lerner A, et al. (2001) Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates. Cell 107(6):739-50 SGD PMID 11747810
- ↑ Jansen JM, et al. (2006) Phosphoregulation of Cbk1 is critical for RAM network control of transcription and morphogenesis. J Cell Biol 175(5):755-66 SGD PMID 17145962
- ↑ Jansen JM, et al. (2009) Cbk1 regulation of the RNA-binding protein Ssd1 integrates cell fate with translational control. Curr Biol 19(24):2114-20 SGD PMID 19962308
- ↑ Kurischko C, et al. (2011) The yeast Cbk1 kinase regulates mRNA localization via the mRNA-binding protein Ssd1. J Cell Biol 192(4):583-98 SGD PMID 21339329
- ↑ Mazanka E and Weiss EL (2010) Sequential Counteracting Kinases Restrict an Asymmetric Gene Expression Program to early G1. Mol Biol Cell 21(16):2809-20 SGD PMID 20573982
- ↑ Mazanka E, et al. (2008) The NDR/LATS family kinase Cbk1 directly controls transcriptional asymmetry. PLoS Biol 6(8):e203 SGD PMID 18715118
- ↑ Nelson B, et al. (2003) RAM: a conserved signaling network that regulates Ace2p transcriptional activity and polarized morphogenesis. Mol Biol Cell 14(9):3782-803 SGD PMID 12972564
- ↑ Panozzo C, et al. (2010) Mutations in the C-terminus of the conserved NDR kinase, Cbk1p of Saccharomyces cerevisiae, make the protein independent of upstream activators. Mol Genet Genomics 283(2):111-22 SGD PMID 19967545
- ↑ Racki WJ, et al. (2000) Cbk1p, a protein similar to the human myotonic dystrophy kinase, is essential for normal morphogenesis in Saccharomyces cerevisiae. EMBO J 19(17):4524-32 SGD PMID 10970846
- ↑ Weiss EL, et al. (2002) The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor. J Cell Biol 158(5):885-900 SGD PMID 12196508
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