Difference between revisions of "YMR190C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004802 YMR190C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SGS1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SGS1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XIII: | + | |nowrap| Chr XIII:645258..640915 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000004802 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000004802 | ||
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| − | '''Description of YMR190C:''' Nucleolar DNA helicase of the RecQ family involved in | + | '''Description of YMR190C:''' Nucleolar DNA helicase of the RecQ family; involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; potential role as repressor of a subset of rapamycin responsive genes; rapidly lost in response to rapamycin in Rrd1p-dependent manner; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes<ref name='S000071163'>Huber MD, et al. (2002) G4 DNA unwinding by BLM and Sgs1p: substrate specificity and substrate-specific inhibition. Nucleic Acids Res 30(18):3954-61 {{SGDpaper|S000071163}} PMID 12235379</ref><ref name='S000127423'>Jessop L and Lichten M (2008) Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis. Mol Cell 31(3):313-23 {{SGDpaper|S000127423}} PMID 18691964</ref><ref name='S000145626'>Marrakchi R, et al. (2011) The isomerase Rrd1 mediates rapid loss of the Sgs1 helicase in response to rapamycin. Biochem Cell Biol () {{SGDpaper|S000145626}} PMID 21639830</ref><ref name='S000127369'>Oh SD, et al. (2008) RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination. Mol Cell 31(3):324-36 {{SGDpaper|S000127369}} PMID 18691965</ref><ref name='S000081521'>Rockmill B, et al. (2003) The Sgs1 helicase regulates chromosome synapsis and meiotic crossing over. Curr Biol 13(22):1954-62 {{SGDpaper|S000081521}} PMID 14614820</ref><ref name='S000055270'>Sun H, et al. (1999) The Saccharomyces cerevisiae Sgs1 helicase efficiently unwinds G-G paired DNAs. Nucleic Acids Res 27(9):1978-84 {{SGDpaper|S000055270}} PMID 10198430</ref><ref name='S000072997'>Versini G, et al. (2003) The yeast Sgs1 helicase is differentially required for genomic and ribosomal DNA replication. EMBO J 22(8):1939-49 |
{{SGDpaper|S000072997}} PMID 12682026</ref> | {{SGDpaper|S000072997}} PMID 12682026</ref> | ||
<br> | <br> | ||
Latest revision as of 06:45, 23 January 2012
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| Systematic name | YMR190C |
| Gene name | SGS1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:645258..640915 |
| Primary SGDID | S000004802 |
Description of YMR190C: Nucleolar DNA helicase of the RecQ family; involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; potential role as repressor of a subset of rapamycin responsive genes; rapidly lost in response to rapamycin in Rrd1p-dependent manner; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes[1][2][3][4][5][6][7]
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References
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- ↑ Huber MD, et al. (2002) G4 DNA unwinding by BLM and Sgs1p: substrate specificity and substrate-specific inhibition. Nucleic Acids Res 30(18):3954-61 SGD PMID 12235379
- ↑ Jessop L and Lichten M (2008) Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis. Mol Cell 31(3):313-23 SGD PMID 18691964
- ↑ Marrakchi R, et al. (2011) The isomerase Rrd1 mediates rapid loss of the Sgs1 helicase in response to rapamycin. Biochem Cell Biol () SGD PMID 21639830
- ↑ Oh SD, et al. (2008) RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination. Mol Cell 31(3):324-36 SGD PMID 18691965
- ↑ Rockmill B, et al. (2003) The Sgs1 helicase regulates chromosome synapsis and meiotic crossing over. Curr Biol 13(22):1954-62 SGD PMID 14614820
- ↑ Sun H, et al. (1999) The Saccharomyces cerevisiae Sgs1 helicase efficiently unwinds G-G paired DNAs. Nucleic Acids Res 27(9):1978-84 SGD PMID 10198430
- ↑ Versini G, et al. (2003) The yeast Sgs1 helicase is differentially required for genomic and ribosomal DNA replication. EMBO J 22(8):1939-49 SGD PMID 12682026
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